Mmp8 - matrix metallopeptidase 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 63849

About Mmp8

Primary_assembly 8: 4,724,029-4,733,520 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 111 orthologues, 23 paralogues and is associated with 19 phenotypes. Biased expression in Spleen (RPKM 36.6), Lung (RPKM 21.7) and 4 other tissues.

Summary

Enables calcium ion binding activity; metallopeptidase activity; and zinc ion binding activity. Involved in several processes, including positive regulation of neuroinflammatory response; positive regulation of nitric oxide biosynthetic process; and positive regulation of tumor necrosis factor production. Located in extracellular space. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in breast Cancer and carotid artery disease. Orthologous to human MMP8 (matrix metallopeptidase 8). [provided by Alliance of Genome Resources, Apr 2022]

Mmp8 Products (1)

mRNA Protein Name
NM_022221.2 NP_071557.2 neutrophil collagenase preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IMP
IMP: Inferred from mutant phenotype
16153442 RGD
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
25049354 RGD
enables metallopeptidase activity IDA
IDA: Inferred from direct assay
16153442 RGD
enables zinc ion binding IMP
IMP: Inferred from mutant phenotype
16153442 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
25049354 RGD
involved in ossification IEP
IEP: Inferred from expression pattern
15052653 RGD
involved in positive regulation of neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
25049354 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
25049354 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
16153442 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
16940237 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neutrophil collagenase

  • MMP-8

  • matrix metalloproteinase-8

  • neutrophil collagenease

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-175275 10-Butyl Ether Minocycline Inhibitor / Phase 3
HY-112160 XL-784 free base Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (32)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148905 p-Aminophenylmercuric acetate Activator 98.32% Unkown
HY-110397 KP-457 Inhibitor 98.88% Unkown
HY-113952 Actinonin 98.37% Unkown
HY-P4931 Mca-KPLGL-Dap(Dnp)-AR-NH2 99.30% Unkown
HY-N1454 Apigenin-7-glucuronide Inhibitor 99.74% Unkown
HY-128133 MMP-8 inhibitor-1 Inhibitor 99.70% Unkown
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.98% Unkown
HY-162038 RXP03 Inhibitor 98.82% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-19485 XL-784 Inhibitor 98.25% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-110116 SD-2590 hydrochloride Inhibitor 99.4% Unkown
HY-147746 MMP2-IN-3 Inhibitor 99.64% Unkown
HY-RS08555 Mmp8 Mouse Pre-designed siRNA Set A / Unkown
HY-113621B Ageladine A dihydrochloride Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-137793 Pro-Leu-Gly-NHOH hydrochloride Inhibitor / Unkown
HY-137839 Anti-inflammatory agent 121 Inhibitor / Unkown
HY-168605 DH-18 / Unkown
HY-180765 Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene Activator / Unkown
HY-182795 Colchicine derivative-1 / Unkown
HY-P10972 GIP (22-51) human / Unkown
HY-P2682 MMP-8/MMP-26 Fluorogenic substrate / Unkown
HY-P3699 TNO003 Substrate / Unkown
HY-RS08554 MMP8 Human Pre-designed siRNA Set A / Unkown
HY-RS08556 Mmp8 Rat Pre-designed siRNA Set A / Unkown
HY-35513 3-Aminobenzene-1,2-diol Inhibitor 98.0% Unkown
HY-43586 BR351 precursor Inhibitor / Unkown
HY-P3699A TNO003 TFA Substrate / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp8 NCBI NCBI:4317