MIF - Mif macrophage migration inhibitory factor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81683

Summary

Predicted to enable several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of transport; response to steroid hormone; and response to vitamin. Located in cytoplasm; extracellular space; and nucleus. Used to study several diseases, including acute necrotizing pancreatitis; cardiomyopathy (multiple); lung disease (multiple); retinitis; and toxic shock syndrome. Biomarker of borna disease; cystitis; kidney disease; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Apr 2022]

MIF Products (1)

mRNA Protein Name
NM_031051.2 NP_112313.1 macrophage migration inhibitory factor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
15947686 RGD
Biological Process GO Annotation Evidence References Source
involved in brain renin-angiotensin system IMP
IMP: Inferred from mutant phenotype
17261648 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
19799867 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
19462902 RGD
involved in drinking behavior IMP
IMP: Inferred from mutant phenotype
16809436 RGD
involved in hair follicle development IEP
IEP: Inferred from expression pattern
16232303 RGD
involved in positive regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
11086030 RGD
involved in positive regulation of acute inflammatory response IMP
IMP: Inferred from mutant phenotype
16455830 RGD
involved in positive regulation of axon regeneration IMP
IMP: Inferred from mutant phenotype
12456989 RGD
involved in positive regulation of glycolytic process IMP
IMP: Inferred from mutant phenotype
11086030 RGD
involved in positive regulation of immune response IMP
IMP: Inferred from mutant phenotype
10617911 RGD
involved in positive regulation of potassium ion transport IMP
IMP: Inferred from mutant phenotype
16267117 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
18270460 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17324399 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
17565848 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
15196698 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
12435855 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
14980085 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
15886670 RGD
involved in response to menaquinone IEP
IEP: Inferred from expression pattern
15856362 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
17324399 RGD
involved in response to vitamin E IEP
IEP: Inferred from expression pattern
10609875 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16571782 RGD
involved in skin development IEP
IEP: Inferred from expression pattern
16232303 RGD
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
15169922 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
15947686 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

macrophage migration inhibitory factor

  • L-dopachrome isomerase

  • L-dopachrome tautomerase

  • glutathione-binding 13 kDa protein

  • macrophage migration inhibitory factor (glycosylation-inhibiting factor)

  • phenylpyruvate tautomerase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17009 Iguratimod Inhibitor 98.49% Yes

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-121356 Carebastine 99.23% Phase 3
HY-105077A Nemifitide diTFA 98.24% Phase 2
HY-16692 ISO-1 Inhibitor 99.84% Phase 1
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99262 Imalumab Inhibitor 98.37% Phase 2

Pre-clinical Phase

Bioactive Molecules (35)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110063 4-IPP Inhibitor 99.40% Unkown
HY-147390 MIF098 Inhibitor 99.99% Unkown
HY-110095 (±)-CPSI-1306 Antagonist 99.64% Unkown
HY-130332 Mitomycin A Inhibitor 98.3% Unkown
HY-W019710 (E,E)-RGFP966 Inhibitor 99.44% Unkown
HY-107663A MIF-1 TFA Modulator 99.34% Unkown
HY-148117 MD13 Inhibitor 99.96% Unkown
HY-110084 BTZO-1 99.32% Unkown
HY-123814 4-CPPC Inhibitor 98.20% Unkown
HY-N10096 Epoxyazadiradione 99.24% Unkown
HY-W164560 RDR 03785 Inhibitor 97.05% Unkown
HY-149308 MKA031 Inhibitor 98.69% Unkown
HY-D0039 3-Cyanoumbelliferone ≥98.0% Unkown
HY-115887 R110 Inhibitor 99.90% Unkown
HY-RS08445 MIF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12386 S100A9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173624 TE-11 Inhibitor / Unkown
HY-107663 MIF-1 Modulator / Unkown
HY-115888 MIF2-IN-1 Inhibitor / Unkown
HY-123970 ISO-92 Inhibitor / Unkown
HY-144190 MIF-IN-1 Inhibitor / Unkown
HY-144196 MIF-IN-4 hydrochloride Inhibitor / Unkown
HY-146318 MIF-IN-5 Inhibitor / Unkown
HY-146319 MIF-IN-6 Inhibitor / Unkown
HY-181912 D-DT/MIF-1-IN-1 Inhibitor / Unkown
HY-182935 PAANIB-1 Inhibitor / Unkown
HY-P3087 Tyr-W-MIF-1 Modulator / Unkown
HY-RS00653 AMH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12385 S100A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W415753 Alaptide / Unkown
HY-155466 Boc-MIF-1-Am Activator / Unkown
HY-174842 HTS05585 Inhibitor / Unkown
HY-RS16522 Mif Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22953 Mif Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00271 Pareptide monohydrochloride / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens MIF NCBI NCBI:4282