2. Gene
  3. EED - embryonic ectoderm development Gene

EED - embryonic ectoderm development Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HEED; COGIS; WAIT1

Gene ID: 8726 | Gene type: protein coding

About EED

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:86,244,753-86,287,615 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and is associated with 68 phenotypes. Ubiquitous expression in lymph node (RPKM 3.3), appendix (RPKM 2.2) and 25 other tissues.

Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of Integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of Integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

EED Products(3)

mRNA Protein Name
NM_001308007.2 NP_001294936.1 polycomb protein EED isoform c
NM_001330334.2 NP_001317263.1 polycomb protein EED isoform d
NM_003797.5 NP_003788.2 polycomb protein EED isoform a

EED Protein Structure

WD40

WD40: WD domain, G-beta repeat (181 - 219)

WD40

WD40: WD domain, G-beta repeat (233 - 263)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 441 a.a.
Protein Preferred Names Protein Names

polycomb protein EED

WD protein associating with integrin cytoplasmic tails 1

Recombinant EED Proteins

Cat. No. Product Name Accession Purity
HY-P74179 EED Protein, Human (sf9, His-GST) O75530 (M1-R441) ≥95%

Related Diseases

Diseases Alias
Cohen-Gibson Syndrome

COGIS
Weaver Syndrome

Wss

Weaver-Smith Syndrome

WVS

Weaver-Like Syndrome

Weaver-Williams Syndrome

Camptodactyly-Overgrowth-Unusual Facies Syndrome

Camptodactyly - Overgrowth - Unusual Facies

Ezh2 Related Overgrowth

Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly

Weaver Smith Syndrome

Weaver Like Syndrome

Weaver Williams Syndrome

Camptodactyly-Overgrowth-Unusual Facies

Weaver Syndrome 1

Weaver Syndrome 2

Wvs1

Wvs2
Atypical Neurofibroma
Diffuse Large B-Cell Lymphoma

Dlbcl

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Large B-Cell Diffuse Lymphoma

Lymphoma, Large B-Cell, Diffuse

Dlbcl - [Diffuse Large B-Cell Lymphoma]

Diffuse Large Beta Cell Lymphoma
Fallopian Tube Endometriosis

Endometriosis Of Fallopian Tube

Adenomyosis Of Fallopian Tube
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-103663 MAK683 Inhibitor 99.27% Phase 2
HY-139400 Pociredir Inhibitor 99.97% Phase 1
HY-139400A Pociredir hydrochloride Inhibitor 99.83% Phase 1
Pre-clinical Phase
Bioactive Molecules (28)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101117 EED226 Inhibitor 99.65% Unkown
HY-101512 A-395 Inhibitor 99.34% Unkown
HY-130708 UNC6852 Inhibitor 99.09% Unkown
HY-130614 PROTAC EED degrader-1 Inhibitor 99.56% Unkown
HY-130615 PROTAC EED degrader-2 Inhibitor 98.64% Unkown
HY-130979 EED226-COOH 98.53% Unkown
HY-158102 ORIC-944 / Unkown
HY-130815A MAK683-CH2CH2COOH hydrochloride Inhibitor 98.03% Unkown
HY-W014099 Boc-NH-C4-acid 99.85% Unkown
HY-132922 EEDi-5273 Inhibitor 98.01% Unkown
HY-136977 EEDi-5285 Inhibitor 99.98% Unkown
HY-130815 MAK683-CH2CH2COOH Inhibitor / Unkown
HY-114176B (S,R,S)-AHPC-C4-NH2 dihydrochloride / Unkown
HY-130816 (S,R,S)-AHPC-O-Ph-PEG1-NH2 96.97% Unkown
HY-114176 (S,R,S)-AHPC-C4-NH2 hydrochloride ≥97.0% Unkown
HY-157164 PROTAC EZH2 Degrader-2 Degrader 98.34% Unkown
HY-W004697 Boc-GABA-OH ≥98.0% Unkown
HY-103663A MAK683 hydrochloride Inhibitor / Unkown
HY-130711A (S,R,S)-AHPC-C3-NH2 TFA / Unkown
HY-114176A (S,R,S)-AHPC-C4-NH2 / Unkown
HY-130638 (S,R,S)-AHPC-O-Ph-PEG1-NH-Boc / Unkown
HY-130711 (S,R,S)-AHPC-C3-NH2 / Unkown
HY-130637 Boc-NH-PEG1-Ph-O-CH2COOH / Unkown
HY-130711C (S,R,S)-AHPC-C3-NH2 dihydrochloride / Unkown
HY-132970 EED ligand 1 Inhibitor / Unkown
HY-P2266 SAH-EZH2 Inhibitor / Unkown
HY-RS04173 EED Human Pre-designed siRNA Set A / Unkown
HY-135045 (S,R,S)-AHPC-C4-COOH / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EED VGNC VGNC:28332
Mus musculus EED MGD MGI:95286
Felis catus EED VGNC VGNC:61731
Macaca mulatta EED VGNC VGNC:72162
Rattus norvegicus EED RGD RGD:1309782
Canis familiaris EED VGNC VGNC:40206
Others EED NCBI