EED - embryonic ectoderm development Gene

Also Known as HEED; COGIS; WAIT1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 8726

About EED

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:86,244,753-86,287,615 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and is associated with 68 phenotypes. Ubiquitous expression in lymph node (RPKM 3.3), appendix (RPKM 2.2) and 25 other tissues.

Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of Integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of Integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

EED Products (3)

mRNA Protein Name
NM_001308007.2 NP_001294936.1 polycomb protein EED isoform c
NM_001330334.2 NP_001317263.1 polycomb protein EED isoform d
NM_003797.5 NP_003788.2 polycomb protein EED isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables enzyme activator activity IDA
IDA: Inferred from direct assay
15385962 GOA
enables enzyme activator activity IMP
IMP: Inferred from mutant phenotype
28229514 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
11124122 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16357870 GOA
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
29628311 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
15385962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EED Protein Structure

WD40

WD40: WD domain, G-beta repeat (181 - 219)

WD40

WD40: WD domain, G-beta repeat (233 - 263)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 441 a.a.
Protein Preferred Names Protein Names

polycomb protein EED

  • WD protein associating with integrin cytoplasmic tails 1

EED Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
EED O75530 SUZ12 Homo sapiens Q15022
Anti Tag CoIP
26496610
Intra
EED O75530 SUZ12 Homo sapiens Q15022
Anti Bait CoIP
22439931
Intra
EED O75530 SUZ12 Homo sapiens Q15022
TAP
27705803
Intra
EED O75530 SUZ12 Homo sapiens Q15022
Anti Tag CoIP
21078963
Intra
EED O75530 ASXL1 Homo sapiens Q8IXJ9
Anti Bait CoIP
22897849
Intra
EED O75530 RACK1 Homo sapiens P63244
Y2H
20080539
Intra
EED O75530 DDB1 Homo sapiens Q16531
Anti Bait CoIP
17041588
Intra
EED O75530 CCT3 Homo sapiens P49368
Crosslink
30021884
Intra
EED O75530 CCT3 Homo sapiens P49368
TAP
27705803
Intra
EED O75530 EZH2 Homo sapiens Q15910
Anti Bait CoIP
22439931
Intra
EED O75530 EZH2 Homo sapiens Q15910
Anti Tag CoIP
26496610
Intra
EED O75530 EZH2 Homo sapiens Q15910
Anti Bait CoIP
22897849
Intra
EED O75530 EZH2 Homo sapiens Q15910
TAP
27705803
Intra
EED O75530 DNMT1 Homo sapiens P26358
Anti Bait CoIP
16357870
Intra
EED O75530 DNMT3B Homo sapiens Q9UBC3
Anti Bait CoIP
16357870
Intra
EED O75530 DNMT3B Homo sapiens Q9UBC3
Pull Down
16357870
Intra
EED O75530 EZH1 Homo sapiens Q92800
TAP
27705803
Intra
EED O75530 DNMT3A Homo sapiens Q9Y6K1
Anti Bait CoIP
16357870
Cross
EED O75530 Smpd3 Mus musculus Q9JJY3
Anti Tag CoIP
20080539
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EED Proteins

製品番号 製品名 アクセッション番号 純度
HY-P74179 EED Protein, Human (sf9, His-GST) O75530 (M1-R441) ≥ 90%, as determined by reducing SDS-PAGE.

EED 抗体

製品番号 製品名 アプリケーション 反応性
HY-P89689 EED Antibody (YA9033) WB, ICC/IF, IF-Tissue, IP, ELISA human

関連疾患

Diseases Alias
Cohen-Gibson Syndrome

  • COGIS
Weaver Syndrome

  • Wss

  • Weaver-Smith Syndrome

  • WVS

  • Weaver-Like Syndrome

  • Weaver-Williams Syndrome

  • Camptodactyly-Overgrowth-Unusual Facies Syndrome

  • Camptodactyly - Overgrowth - Unusual Facies

  • Ezh2 Related Overgrowth

  • Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly

  • Weaver Smith Syndrome

  • Weaver Like Syndrome

  • Weaver Williams Syndrome

  • Camptodactyly-Overgrowth-Unusual Facies

  • Weaver Syndrome 1

  • Weaver Syndrome 2

  • Wvs1

  • Wvs2
Atypical Neurofibroma
Diffuse Large B-Cell Lymphoma

  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma
Fallopian Tube Endometriosis

  • Endometriosis Of Fallopian Tube

  • Adenomyosis Of Fallopian Tube
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
製品番号 製品名 製品効果
純度 Phase
HY-139400A Pociredir hydrochloride Inhibitor 99.89% Phase 2
HY-158102 Rinzimetostat Inhibitor 99.90% Phase 1
HY-103663 MAK683 Inhibitor 99.02% Phase 1
HY-132922 EEDi-5273 Inhibitor 99.48% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-101117 EED226 Inhibitor 99.56% Unkown
HY-130708 UNC6852 Inhibitor 98.49% Unkown
HY-101512 A-395 Inhibitor 99.12% Unkown
HY-139400 Pociredir Inhibitor 99.97% Unkown
HY-148334 MS8815 Degrader 99.95% Unkown
HY-W004697 Boc-GABA-OH 99.14% Unkown
HY-W014099 Boc-NH-C4-acid 99.65% Unkown
HY-130615 PROTAC EED degrader-2 Inhibitor 99.90% Unkown
HY-130979 EED226-COOH Degrader 99.88% Unkown
HY-130815A MAK683-C2-acid hydrochloride Inhibitor 99.60% Unkown
HY-136977 EEDi-5285 Inhibitor 99.87% Unkown
HY-160924 MS147 Degrader 98.31% Unkown
HY-130614 PROTAC EED degrader-1 Inhibitor 99.18% Unkown
HY-158239 MS181 98.36% Unkown
HY-135045 (S,R,S)-AHPC-C4-COOH 95.92% Unkown
HY-158102A Rinzimetostat TFA 99.82% Unkown
HY-132970 EED ligand 1 Inhibitor 99.93% Unkown
HY-130815 MAK683-CH2CH2COOH Inhibitor / Unkown
HY-114176B (S,R,S)-AHPC-C4-NH2 dihydrochloride / Unkown
HY-130816 (S,R,S)-AHPC-O-Ph-PEG1-NH2 96.97% Unkown
HY-114176 (S,R,S)-AHPC-C4-NH2 hydrochloride 99.69% Unkown
HY-P2266 SAH-EZH2 Inhibitor 99.50% Unkown
HY-RS04173 EED Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103663A MAK683 hydrochloride Inhibitor / Unkown
HY-130711A (S,R,S)-AHPC-C3-NH2 TFA / Unkown
HY-114176A (S,R,S)-AHPC-C4-NH2 / Unkown
HY-130638 (S,R,S)-AHPC-O-Ph-PEG1-NH-Boc / Unkown
HY-130711 (S,R,S)-AHPC-C3-NH2 / Unkown
HY-101512D rel-A-395 hydrochloride Inhibitor / Unkown
HY-130637 Boc-NH-PEG1-Ph-O-CH2COOH / Unkown
HY-130711C (S,R,S)-AHPC-C3-NH2 dihydrochloride 95.0% Unkown
HY-148641 ZJH-16 Inhibitor / Unkown
HY-168131 PROTAC EZH2 Degrader-3 / Unkown
HY-174372 EZH2-IN-23 Inhibitor / Unkown
HY-174397 EED-IN-3 Inhibitor / Unkown
HY-178694 DC-PRC2in-01 Inhibitor / Unkown
HY-181308 PROTAC EZH2 Degrader-13 Degrader / Unkown
HY-181320 PROTAC EZH2 Degrader-19 Degrader / Unkown
HY-181323 PROTAC EZH2 Degrader-22 Degrader / Unkown
HY-181392 PROTAC EZH2 Degrader-35 Degrader / Unkown
HY-181413 PROTAC EZH2 Degrader-44 / Unkown
HY-182365 EED-IN-4 Inhibitor / Unkown
HY-182366 EED-IN-5 Inhibitor / Unkown
HY-124660A A-395N / Unkown
HY-RS16662 Eed Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23097 Eed Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus EED VGNC VGNC:28332
Mus musculus EED MGD MGI:95286
Felis catus EED VGNC VGNC:61731
Macaca mulatta EED VGNC VGNC:72162
Rattus norvegicus EED RGD RGD:1309782
Canis familiaris EED VGNC VGNC:40206
Others EED NCBI