HDAC/NAMPT-IN-1

ADC Targets in Oncology

2026-04-10

Cell Line	Type	Value	Description	References
HL-60	GI₅₀	51.2 nM Compound: 39h	Antiproliferative activity against p53-null human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis Antiproliferative activity against p53-null human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis	[PMID: 38224650]
Kasumi 1	GI₅₀	21.38 nM Compound: 39h	Antiproliferative activity against human Kasumi 1 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis Antiproliferative activity against human Kasumi 1 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis	[PMID: 38224650]
MV4-11	GI₅₀	23.6 nM Compound: 39h	Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis	[PMID: 38224650]
MV4-11	IC₅₀	29.6 nM Compound: 39h	Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis	[PMID: 38224650]
NB-4	GI₅₀	16.47 nM Compound: 39h	Antiproliferative activity against p53-null human NB4 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis Antiproliferative activity against p53-null human NB4 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis	[PMID: 38224650]

Cell Line

Type

Value

Description

References

HL-60

GI₅₀

51.2 nM

Compound: 39h

Antiproliferative activity against p53-null human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis

[PMID: 38224650]

Kasumi 1

GI₅₀

21.38 nM

Compound: 39h

Antiproliferative activity against human Kasumi 1 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis

[PMID: 38224650]

MV4-11

GI₅₀

23.6 nM

Compound: 39h

Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis

[PMID: 38224650]

MV4-11

IC₅₀

29.6 nM

Compound: 39h

Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis

[PMID: 38224650]

NB-4

GI₅₀

16.47 nM

Compound: 39h

Antiproliferative activity against p53-null human NB4 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis

[PMID: 38224650]

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HDAC/NAMPT-IN-1

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HDAC/NAMPT-IN-1 Related Classifications

HY-162124 Related Classifications