HDAC6-IN-43
HDAC6-IN-43 (compound 26) is a potent HDAC inhibitor. HDAC6-IN-43 effectively inhibits several HDACs, notably HDAC1, HDAC2, and HDAC6 (IC50 < 150 nM), displaying a particularly high sensitivity towards HDAC6 (IC50 = 11 nM). HDAC6-IN-43 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).
For research use only. We do not sell to patients.
- CAS No.: 3037978-19-8
- Formula: C21H24N2O4S
- Molecular Weight:400.49
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
|
HDAC6 11 ± 1 nM (IC50) |
HDAC2 105 ± 5 nM (IC50) |
HDAC1 111 ± 5 nM (IC50) |
HDAC8 15404 ± 99 nM (IC50) |
In Vitro
HDAC6-IN-43 (compound 26) significantly inhibits Madin-Darby canine kidney (MDCK) cell growth and proliferation by upregulating the acetylation of α-tubulin levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 3037978-19-8
-
Molecular Weight 400.49
-
Formula C21H24N2O4S
-
SMILES
COC1=C(OCCCCCCC(NO)=O)C=C(C2=NC3=CC=CC=C3S2)C=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)