Siccanin
Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC50=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi.
For research use only. We do not sell to patients.
- CAS No.: 22733-60-4
- Formula: C22H30O3
- Molecular Weight:342.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Succinate Dehydrogenase Inhibitor
Siccanin (10 μg/mL) is species-selective, and Siccanin inhibits bacterial SDH from P. aeruginosa and P. putida but not SDH from E. coli, and C. glutamicum; Siccanin inhibits rodent SDH but not porcine SDH[1].
Specifically, Siccanin inhibits SDH from P. aeruginosa (residual activity 13%) and P. putida (>1%) membranes, and of mouse (>7%) and rat (19%) liver mitochondria, but not SDH from E. coli (77%) and C. glutamicum (97%) membranes and of porcine heart mitochondria (106%)[1].
Siccanin (3 μg/mL) competely inhibits the growth of Trichophyton mentagrophytes (IC50=0.3 μg/mL)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 22733-60-4
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Molecular Weight 342.47
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Formula C22H30O3
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SMILES
C[C@@]12[C@@]3([H])[C@@]4(CO[C@@]3([H])C5=C(O)C=C(C)C=C5O2)[C@@](C(C)(CCC4)C)([H])CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Siccanin Related Classifications
HY-106371 Related Classifications
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