Cat. No.: HY-N0894

Octahydrocurcumin

(Synonyms: Hexahydrobisdemethoxycurcumin)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively.

For research use only. We do not sell to patients.

Purity: 99.25%
CAS No.: 36062-07-4
Formula: C₂₁H₂₈O₆
Molecular Weight:376.44

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Octahydrocurcumin Chemical Structure

CAS No.: 36062-07-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

COX-2

TAK1

All MAP4K Isoforms :

All NF-κB Isoforms :

All COX Isoforms :

In Vivo

Octahydrocurcumin (5-20 mg/kg; i.g.; daily; 7 days) exerts potent dose-dependent anti-HCC activity in H22 ascites tumor-bearing mice, with 20 mg/kg OHC increasing survival by 78.98%, reducing ascites volume and cancer cell viability, inducing apoptosis, and modulating mitochondrial pathway-related proteins more effectively than 100 mg/kg curcumin, without immune organ toxicity^[1].
Octahydrocurcumin (10-40 mg/kg; i.g.; daily; 7 days) dose-dependently inhibits xylene-induced mouse ear edema, achieving a maximum suppression rate of 70.67% at 40 mg/kg^[2].
Octahydrocurcumin (10-40 mg/kg; i.g.; daily; 7 days) dose-dependently reduces acetic acid-induced vascular permeability in mice, reaching a 48.0% suppression rate at 40 mg/kg^[2].
Octahydrocurcumin (10-40 mg/kg; i.g.; daily; 7 days) dose-dependently inhibits Carrageenan (HY-125474)-induced mouse paw edema, reduces pro-inflammatory mediator production, selectively suppresses COX-2 expression, and blocks the TAK1-NF-κB pathway^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming (KM) (male, 18-22 g, intraperitoneal injection of H22 cell suspension to establish HCC ascites model)^[1]
Dosage:

5 mg/kg; 10 mg/kg; 20 mg/kg
Administration:

i.g.; daily; 7 days
Result:

Increased survival rates by 26.13%, 50%, and 78.98% respectively compared to vehicle control; 20 mg/kg dose resulted in a significantly higher survival rate than 100 mg/kg curcumin.
Suppressed increases in body weight and abdominal circumference compared to vehicle control; 20 mg/kg dose resulted in significantly lower body weight and abdominal circumference than 100 mg/kg curcumin on day 7.
Showed no significant difference in spleen and thymus indexes compared to intact, vehicle, and curcumin groups at 20 mg/kg dose.
Reduced ascites volume significantly more than 100 mg/kg curcumin at 20 mg/kg dose.
Reduced cancer cellular viability significantly more than 100 mg/kg curcumin at 20 mg/kg dose.
Significantly increased the apoptotic rate of ascitic cells compared to 100 mg/kg curcumin at 20 mg/kg dose.
Upregulated p53, Bax, Bad, cytochrome C, cleaved caspase-9, cleaved caspase-3, and cleaved PARP protein expressions, and downregulated MDM2, Bcl-2, and Bcl-xl protein expressions to a greater extent than 100 mg/kg curcumin at 20 mg/kg dose; also upregulated Bax mRNA and downregulated Bcl-2 mRNA expression.

Animal Model:

ICR mice (male and female, 18-22 g)^[2]
Dosage:

10 mg/kg; 20 mg/kg; 40 mg/kg
Administration:

i.g.; daily; 7 days
Result:

Inhibited ear edema with suppression rates of 37.33%, 57.33%, and 70.67% at 10, 20, and 40 mg/kg, respectively.\nInhibited vascular permeability with a maximum suppression ratio of 48.0% at 40 mg/kg.\nAttenuated paw edema dose-dependently from 1 to 6 hours post-carrageenan injection.
Exhibited edema inhibition ratios of 35.87% at 4 hours, 45.16% at 5 hours, and 53.41% at 6 hours at 40 mg/kg.
Significantly reduced carrageenan-induced increases in IL-1β, IL-6, TNF-α, and PGE2 levels at 40 mg/kg, with greater inhibitory activity than curcumin.
Selectively downregulated COX-2 gene and protein expression without affecting COX-1 at 40 mg/kg.
Inhibited TAK1 phosphorylation, reduced TAB1 protein expression, suppressed IKKβ and IκBα phosphorylation, and prevented NF-κB (p65) translocation from the cytosol to the nucleus at 40 mg/kg.

Chemical Information

CAS No. 36062-07-4
Appearance Solid-Liquid Mixture
Molecular Weight 376.44
Formula C₂₁H₂₈O₆
Color Light yellow to yellow
SMILES

OC(CC(O)CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
Synonyms

Hexahydrobisdemethoxycurcumin
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

University of Edinburgh

2025 May 29.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (265.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 10 mg/mL (26.56 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6565 mL

13.2823 mL

26.5647 mL

5 mM

0.5313 mL

2.6565 mL

5.3129 mL

10 mM

0.2656 mL

1.3282 mL

2.6565 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 3.75 mg/mL (9.96 mM); Clear solution

This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 3.75 mg/mL (9.96 mM); Clear solution

This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 3.75 mg/mL (9.96 mM); Clear solution

This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Z , et al. Octahydrocurcumin, a final hydrogenated metabolite of curcumin, possesses superior anti-tumor activity through induction of cellular apoptosis. Food Funct. 2018;9(4):2005-2014. [Content Brief]

[2]. Zhang ZB, et al. Curcumin's Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway. Front Pharmacol. 2018;9:1181. Published 2018 Oct 17. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	2.6565 mL	13.2823 mL	26.5647 mL	66.4116 mL
	5 mM	0.5313 mL	2.6565 mL	5.3129 mL	13.2823 mL
	10 mM	0.2656 mL	1.3282 mL	2.6565 mL	6.6412 mL
	15 mM	0.1771 mL	0.8855 mL	1.7710 mL	4.4274 mL
	20 mM	0.1328 mL	0.6641 mL	1.3282 mL	3.3206 mL
	25 mM	0.1063 mL	0.5313 mL	1.0626 mL	2.6565 mL
DMSO	30 mM	0.0885 mL	0.4427 mL	0.8855 mL	2.2137 mL
	40 mM	0.0664 mL	0.3321 mL	0.6641 mL	1.6603 mL
	50 mM	0.0531 mL	0.2656 mL	0.5313 mL	1.3282 mL
	60 mM	0.0443 mL	0.2214 mL	0.4427 mL	1.1069 mL
	80 mM	0.0332 mL	0.1660 mL	0.3321 mL	0.8301 mL
	100 mM	0.0266 mL	0.1328 mL	0.2656 mL	0.6641 mL

Octahydrocurcumin

1 Cited Publications

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Octahydrocurcumin

Apoptosis Compound Library

Immunology/Inflammation Compound Library

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MAPK Compound Library

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Publications Citing Use of MedChemExpress (MCE) Octahydrocurcumin

All MAP4K Isoforms

All NF-κB Isoforms

All COX Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Octahydrocurcumin Related Classifications

HY-N0894 Related Classifications