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Irs1 - insulin receptor substrate 1 Gene

Also Known as IRS1IRM

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25467

Summary

Enables several functions, including SH2 domain binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; regulation of Insulin Receptor signaling pathway; and regulation of peptide hormone secretion. Located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Part of Insulin Receptor complex. Used to study end stage renal disease; obesity; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; non-alcoholic fatty liver disease; and osteoporosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human IRS1 (Insulin Receptor substrate 1). [provided by Alliance of Genome Resources, Apr 2022]

Irs1 Products (1)

mRNA	Protein	Name
NM_012969.2	NP_037101.2	insulin receptor substrate 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH2 domain binding	IPI IPI: Inferred from physical interaction	8491186	RGD
enables insulin receptor binding	IMP IMP: Inferred from mutant phenotype	12850498	RGD
enables insulin-like growth factor receptor binding	IPI IPI: Inferred from physical interaction	15272025	RGD
enables phosphatidylinositol 3-kinase binding	IDA IDA: Inferred from direct assay	1380456	RGD
enables phosphatidylinositol 3-kinase binding	IMP IMP: Inferred from mutant phenotype	12850498	RGD
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	12891559	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	1380456	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	12891559	RGD
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	18285345	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15701573	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15272025	RGD
enables transmembrane receptor protein tyrosine kinase adaptor activity	IMP IMP: Inferred from mutant phenotype	18285345	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	8579617	RGD
involved in cellular response to brain-derived neurotrophic factor stimulus	IEP IEP: Inferred from expression pattern	17467122	RGD
involved in cellular response to radiation	IEP IEP: Inferred from expression pattern	17427956	RGD
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	17925406	RGD
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15069075	RGD
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	12435589	RGD
involved in negative regulation of somatostatin secretion	IMP IMP: Inferred from mutant phenotype	12435589	RGD
involved in positive regulation of glucagon secretion	IMP IMP: Inferred from mutant phenotype	12435589	RGD
involved in positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18285345	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	1380456	RGD
involved in positive regulation of phosphorylation	IDA IDA: Inferred from direct assay	12435589	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	22015326	RGD
involved in response to caffeine	IDA IDA: Inferred from direct assay	21940847	RGD
involved in response to caffeine	IEP IEP: Inferred from expression pattern	22995397	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of insulin receptor complex	IMP IMP: Inferred from mutant phenotype	15069075	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
insulin receptor substrate 1	IRS-1 pp185

Irs1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Irs1	P35570	Phip	Mus musculus	Q8VDD9	Y2H	11018022
Cross	Irs1	P35570	TP53BP2	Homo sapiens	Q13625-2	Pull Down	17965023
Cross	Irs1	P35570	GRB2	Homo sapiens	P62993	Competition Binding	8491186
Cross	Irs1	P35570	GRB2	Homo sapiens	P62993	Pull Down	7504175
Cross	Irs1	P35570	GRB2	Homo sapiens	P62993	CoIP	8491186
Cross	Irs1	P35570	INSR	Homo sapiens	P06213	Phosphatase Assay	11136729
Cross	Irs1	P35570	INSR	Homo sapiens	P06213	Protein Kinase Assay	10660596
Cross	Irs1	P35570	INSR	Homo sapiens	P06213	Y2H	15629149
Intra	Irs1	P35570	Pik3r1	Rattus norvegicus	Q63787	CoIP	11136729
Intra	Irs1	P35570	Pik3r1	Rattus norvegicus	Q63787	CoIP	12446583
Cross	Irs1	P35570	Fyn	Mus musculus	P39688	Pull Down	8631859
Cross	Irs1	P35570	PIK3R1	Homo sapiens	P27986	Far-WB	10660596
Intra	Irs1	P35570	Pabpc1	Rattus norvegicus	Q9EPH8	Anti Bait CoIP	23770097
Cross	Irs1	P35570	PTPN1	Homo sapiens	P18031	Phosphatase Assay	10660596

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153479	Aganirsen	Inhibitor	/	Phase 3
HY-145935	NT219	Inhibitor	98.57%	Phase 2
HY-115461	MID-1	Inhibitor	99.36%	Phase 2

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113402	Gamma-glutamylcysteine		98.53%	Unkown
HY-100037	NT157	Inhibitor	99.38%	Unkown
HY-12557	γ-Glutamylvaline		99.94%	Unkown
HY-113402A	Gamma-glutamylcysteine TFA		96.68%	Unkown
HY-B1885	Fenitrothion		99.43%	Unkown
HY-N0479	Licarin B	Activator	99.93%	Unkown
HY-161321	PTP1B-IN-24		98.46%	Unkown
HY-113402R	Gamma-glutamylcysteine (Standard)		98.14%	Unkown
HY-N2421	Sequoyitol		98.0%	Unkown
HY-15113A	Y-29794 tosylate	Inhibitor	99.86%	Unkown
HY-N3542	Carpachromene	Inhibitor	98.84%	Unkown
HY-N3628	Coronarin A	Inhibitor	≥98.0%	Unkown
HY-113402AR	Gamma-glutamylcysteine TFA (Standard)		/	Unkown
HY-15113	Y-29794	Inhibitor	/	Unkown
HY-153479A	Aganirsen sodium	Inhibitor	/	Unkown
HY-162499	MY17	Inhibitor	/	Unkown
HY-182558	Nandinine		/	Unkown
HY-B1885S	Fenitrothion-d6		/	Unkown
HY-N0479S	Licarin B-d4		/	Unkown
HY-P5433F	IRS-1 Peptide, FAM labeled	Substrate	/	Unkown
HY-RS06917	IRS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-107758	Y-29794 oxalate	Inhibitor	/	Unkown
HY-113402B	Gamma-glutamylcysteine ammonium		/	Unkown
HY-N10035	Cyclocarioside H		/	Unkown
HY-N3055	Pinusolide		99.93%	Unkown
HY-RS16895	Irs1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23337	Irs1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Irs1	NCBI	NCBI:3667