Amorphigenin
Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders.
For research use only. We do not sell to patients.
- CAS No.: 4208-09-7
- Formula: C23H22O7
- Molecular Weight:410.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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c-Fos |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | ED50 |
0.05 μg/mL
Compound: 5
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 8326318] |
| HCT-8 | ED50 |
0.03 μg/mL
Compound: 5
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Cytotoxicity against human HCT8 cells
Cytotoxicity against human HCT8 cells
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[PMID: 8326318] |
| KB | ED50 |
0.04 μg/mL
Compound: 5
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 8326318] |
| LNCaP | ED50 |
0.3 μM
Compound: 7
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Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
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[PMID: 32459967] |
| LNCaP | ED50 |
7.9 μg/mL
Compound: 7
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Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
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[PMID: 17125241] |
| Lu1 | ED50 |
4.8 μg/mL
Compound: 7
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Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
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[PMID: 17125241] |
| MCF7 | ED50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 17125241] |
| P388 | ED50 |
0.04 μg/mL
Compound: 5
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 8326318] |
| RPMI-7951 | ED50 |
0.05 μg/mL
Compound: 5
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Cytotoxicity against human RPMI7951 cells
Cytotoxicity against human RPMI7951 cells
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[PMID: 8326318] |
| TE-671 | ED50 |
<0.01 μg/mL
Compound: 5
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Cytotoxicity against human TE671 cells
Cytotoxicity against human TE671 cells
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[PMID: 8326318] |
Chemical Information
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CAS No. 4208-09-7
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Molecular Weight 410.42
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Formula C23H22O7
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SMILES
O=C1[C@@]2([C@]([H])(OC3=C1C=CC4=C3C[C@@H](O4)C(CO)=C)COC5=C2C=C(C(OC)=C5)OC)[H]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lee KW, et al. Root Extract Induces Autophagy-Mediated Melanosome Degradation in mTOR-Independent- and AMPK-Dependent Manner. Curr Issues Mol Biol. 2022 Jun 29;44(7):2856-2867. [Content Brief]
[2]. Kim BG, et al. Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells. Anat Cell Biol. 2010 Dec;43(4):310-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Amorphigenin Related Classifications
HY-116640 Related Classifications
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