Cat. No.: HY-128754

Monoolein

(Synonyms: MG (18:1))

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Monoolein is a biocompatible lipid molecule that can be used as a carrier for bone repair. Monoolein exhibits anti-inflammatory activity by inhibiting the immune response induced by LPS (HY-D1056). It exerts its anti-inflammatory effects by reducing the production of immune response factors such as IL-12 p40, IL-6, and TNF-α, and inhibiting the generation of NO. Monoolein can be used in drug delivery and research in the field of inflammatory diseases .

For research use only. We do not sell to patients.

Purity: 99.90%
CAS No.: 111-03-5
Formula: C₂₁H₄₀O₄
Molecular Weight:356.54

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Monoolein Chemical Structure

CAS No.: 111-03-5

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

All NO Synthase Isoforms :

In Vitro

Monoolein (1-10 μM, 1 hour) exerts anti-inflammatory effects in BMDCs and RAW264.7 cells by inhibiting LPS-induced immune responses, manifested as a reduction in IL-12 p40, IL-6, and TNF-α levels in BMDCs, and suppression of NO, IL-12 p40, IL-6, and TNF-α production in RAW264.7 cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Bone marrow-derived dendritic cells (BMDCs)
Concentration:

1-10 μM
Incubation Time:

1 h
Result:

Significantly reduced the levels of IL-12 p40, IL-6, and TNF-α in BMDCs.

In Vivo

Monoolein (carrying 5 μg rhBMP-2, applied to the bone defect area for 3 weeks and 6 weeks) can serve as a carrier for rhBMP-2, playing a role in bone repair and demonstrating good biocompatibility and protein release properties ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (200 g)
Dosage:

Monoolein carrier with rhBMP-2, 5 μg of rhBMP-2 per rat
Administration:

3 weeks or 6 weeks, single dose, Monoolein combined with rhBMP-2 applied to bone defect site
Result:

Promoted new bone formation, with better repair at 6 weeks compared to 3 weeks.

Chemical Information

CAS No. 111-03-5
Appearance Oil
Molecular Weight 356.54
Formula C₂₁H₄₀O₄
Color White to light yellow
SMILES

CCCCCCCC/C=C\CCCCCCCC(OCC(O)CO)=O
Synonyms

MG (18:1)
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Metabolites

Review of Biological Activities of Some Rare Oils from Amazonian Plants. [Abstract]

2025 Aug 19;15(8):554. PMID: 40863170

Solvent & Solubility

In Vitro:

Ethanol : 100 mg/mL (280.47 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8047 mL

14.0237 mL

28.0473 mL

5 mM

0.5609 mL

2.8047 mL

5.6095 mL

10 mM

0.2805 mL

1.4024 mL

2.8047 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.01 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.01 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ali I, et al. Monoolein, isolated from Ishige sinicola, inhibits lipopolysaccharide-induced inflammatory response by attenuating mitogen-activated protein kinase and NF-κB pathways. Food Sci Biotechnol. 2017 Apr 30;26(2):507-511. [Content Brief]

[2]. Issa JP, et al. Monoolein and chitosan gels as potential carriers of the rhBMP-2, using decortication surgical technique in Wistar rats as experimental model. Micron. 2008 Oct;39(7):952-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol	1 mM	2.8047 mL	14.0237 mL	28.0473 mL	70.1184 mL
	5 mM	0.5609 mL	2.8047 mL	5.6095 mL	14.0237 mL
	10 mM	0.2805 mL	1.4024 mL	2.8047 mL	7.0118 mL
	15 mM	0.1870 mL	0.9349 mL	1.8698 mL	4.6746 mL
	20 mM	0.1402 mL	0.7012 mL	1.4024 mL	3.5059 mL
	25 mM	0.1122 mL	0.5609 mL	1.1219 mL	2.8047 mL
	30 mM	0.0935 mL	0.4675 mL	0.9349 mL	2.3373 mL
	40 mM	0.0701 mL	0.3506 mL	0.7012 mL	1.7530 mL
	50 mM	0.0561 mL	0.2805 mL	0.5609 mL	1.4024 mL
	60 mM	0.0467 mL	0.2337 mL	0.4675 mL	1.1686 mL
	80 mM	0.0351 mL	0.1753 mL	0.3506 mL	0.8765 mL
	100 mM	0.0280 mL	0.1402 mL	0.2805 mL	0.7012 mL

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Monoolein

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Publications Citing Use of MedChemExpress (MCE) Monoolein

All Endogenous Metabolite Isoforms

All TNF Receptor Isoforms

All Interleukin Related Isoforms

All NO Synthase Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Monoolein Related Classifications

HY-128754 Related Classifications