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BX795

41 Cited Publications
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Based on 41 publication(s) in Google Scholar

BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKε, with an IC50 of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy.

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  • 純度: 99.84%
  • CAS 番号: 702675-74-9
  • 分子式: C23H26IN7O2S
  • 分子量:591.47
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • BX795 Chemical Structure
    BX795 構造式
  • Experimental Validation Results for BX795
  • Experimental Validation Results for BX795
  • Experimental Validation Results for BX795
  • Experimental Validation Results for BX795
  • Experimental Validation Results for BX795
CAS 番号: 702675-74-9
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  • BX795 Chemical Structure
    BX795 Chemical Structure
    1/16
  • 1/16

    BX795 purchased from MedChemExpress. Usage Cited in: Nature. 2022 Oct;610(7933):761-767. [Abstract]

    Customer Validation
     HeLa cells pretreated with DMSO or 2 µM BX795 for 24 h are stimulated with 2.5 µM diABZI or not and analysed by Western blot.

  • 1/16

    BX795 purchased from MedChemExpress. Usage Cited in: Fitoterapia. 2019 Apr:134:14-22. [Abstract]

    Customer Validation
     BT474 cells are exposed to protoapigenone, apigenin and BX-795 using different administration combination and analyzed by Western blot, β-actin was used as internal control.

  • 1/16

    BX795 purchased from MedChemExpress. Usage Cited in: Fitoterapia. 2019 Apr:134:14-22. [Abstract]

    Customer Validation
     MDA-MB-231 cells are exposed to protoapigenone, apigenin and BX-795 using different administration combination and analyzed by Western blot, β-actin was used as internal control.

  • 1/16

    BX795 purchased from MedChemExpress. Usage Cited in: Mol Cell Proteomics. 2018 Dec;17(12):2434-2447.  [Abstract]

    Customer Validation
     Relative A427 cell counts upon 96 hrs siRNA-mediated knockdown of PDPK1 and/or AURKA and/or 72 hrs treatment with 250 nM BX795.

  • 1/16

    BX795 purchased from MedChemExpress. Usage Cited in: Autophagy. 2017 Jan 2;13(1):133-148. [Abstract]

    Customer Validation
     HeLa cells are treated with a BX795 TBK1 inhibitor (1 μM) and MG132 (10 μM) for 12 h. Cell lysates are analyzed by immunoblot analysis. Band intensities are measured, and phosphorylated-SQSTM1 values are normalized to total SQSTM1. The combined MG132/BX795 treatment results in a 90% reduction in S403 phosphorylation but has no effect on S349 phosphorylation.

  • BX795