MC-DOXHZN
Based on 5 publication(s) in Google Scholar
MC-DOXHZN ((E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone) is an albumin-binding proagent of Doxorubicin (HY-15142A) (DNA topoisomerase II inhibitor), with acid-sensitive properties. MC-DOXHZN can be used to synthesize ADC.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 151038-96-9
- 分子式: C37H42N4O13
- 分子量:750.75
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Daunorubicins/Doxorubicins |
化学情報
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CAS 番号 151038-96-9
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分子量 750.75
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分子式 C37H42N4O13
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SMILES
[H][C@@]1(O[C@H]2C[C@@](/C(CO)=N\NC(CCCCCN3C(C=CC3=O)=O)=O)(O)CC(C2=C4O)=C(O)C5=C4C(C6=C(OC)C=CC=C6C5=O)=O)O[C@@H](C)[C@@H](O)[C@@H](N)C1
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別名
(E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Int J Pharm
Dual-targeting hybrid peptide-conjugated doxorubicin for drug resistance reversal in breast cancer. [Abstract]2016 Oct 15;512(1):1-13. PMID: 27521706 -
Mol Pharm
Albumin Binding Domain Fusing R/K-X-X-R/K Sequence for Enhancing Tumor Delivery of Doxorubicin. [Abstract]2017 Nov 6;14(11):3739-3749. PMID: 28950700 -
Mol Pharm
Acid-Sensitive Peptide-Conjugated Doxorubicin Mediates the Lysosomal Pathway of Apoptosis and Reverses Drug Resistance in Breast Cancer. [Abstract]2015 Jul 6;12(7):2217-28. PMID: 26035464 -
Bioconjug Chem
Microenvironmental Control of MUC1 Aptamer-Guided Acid-Labile Nanoconjugate within Injectable Microporous Hydrogels. [Abstract]2017 Oct 18;28(10):2530-2537. PMID: 28949511 -
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MC-DOXHZN 関連分類
HY-16261A 関連分類
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- MC-DOXHZN
- 151038-96-9
- (E/Z)-Aldoxorubicin
- Doxorubicin(6-maleimidocaproyl)hydrazone
- ADC Payloads
- Topoisomerase
- thiol-containing monoclonal antibodies
- L2987 human lung adenocarcinoma cells
- human IgG
- chimeric BR96
- Michael addition reaction
- DTT-thiolated monoclonal antibodies
- human lung adenocarcinoma cells
- lysosomal-mimicking conditions
- chimeric BR96 monoclonal antibody
- monoclonal antibodies
- Inhibitor
- inhibitor
- inhibit