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Ebselen

(別名: エブセレン; SPI-1005; PZ-51; CCG-39161)
27 Cited Publications
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Based on 27 publication(s) in Google Scholar

Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM).Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity.

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  • 純度: 99.80%
  • CAS 番号: 60940-34-3
  • 分子式: C13H9NOSe
  • 分子量:274.18
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Ebselen Chemical Structure
    Ebselen 構造式
  • Experimental Validation Results for Ebselen
  • Experimental Validation Results for Ebselen
  • Experimental Validation Results for Ebselen
  • Experimental Validation Results for Ebselen
  • Experimental Validation Results for Ebselen
  • Experimental Validation Results for Ebselen
CAS 番号: 60940-34-3
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  • Ebselen Chemical Structure
    Ebselen Chemical Structure
    1/16
  • 1/16

    Ebselen purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 24;16(1):3874. [Abstract]

    Customer Validation
     Treatment of both GBM12 and GBM28 cells with ROS scavenger, Ebselen (25 μM) also reduced virus-induced lipid peroxidation.

  • 1/16

    Ebselen purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 19;16(1):10181. [Abstract]

    Customer Validation
     Representative H&E images showing testis morphology of aged Ctrl and cKO mice, Ctrl and cKO mice with Ebselen (20 mg/kg/day, ip, one month) treatment, and cOE mice (conditional overexpression of PRDX1 in LCs).

  • 1/16

    Ebselen purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 19;16(1):10181. [Abstract]

    Customer Validation
     We found that Ebselen (20 mg/kg/day, ip, one month) treatment effectively improved the parameters for memory, behavior, and maximal exercise capacity in both aged Ctrl and cKO mice, as revealed by the number of alternation behaviors (measured by Y-maze test), the total distance and exploratory behavior (measured by open field trail), and the time to exhaustion (measured by run-to-exhaustion test).

  • 1/16

    Ebselen purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 19;16(1):10181. [Abstract]

    Customer Validation
     Both Ebselen (20 mg/kg/day, ip, one month) treatment and PRDX1 overexpression significantly increased autophagosome-LD contact.

  • 1/16

    Ebselen purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 19;16(1):10181. [Abstract]

    Customer Validation
     Ebselen (20 mg/kg/day, ip, one month) treatment also increased sperm count in aged cKO mice, and both Ebselen treatment and PRDX1 overexpression greatly enhanced sperm motility.

  • 1/16

    Ebselen purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2019 Feb;17(2):1412-1419. [Abstract]

    Customer Validation
     Ebselen influences the expression of apoptosis‑related proteins. The effects of ebselen on C‑Caspase‑8, C‑Caspase‑3, Bax, Bcl‑2 and C‑PARP are analyzed by western blotting.

  • Ebselen