Netilmicin (sulfate)
Based on 1 Customer Validation
Netilmicin (Sch 20569) sulfate is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin sulfate exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 56391-57-2
- 分子式: C21H41N5O7.5/2H2SO4
- 分子量:720.78
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Antibiotic アイソフォーム固有の製品をすべて表示
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生物活性
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Aminoglycoside |
Netilmicin sulfate exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Netilmicin (i.v.: LD50 of 40 mg/kg; i.p.: LD50 of 125 mg/kg; s.c.: LD50 of 175 mg/kg) sulfate has a higher acute toxicity than Gentamicin in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 56391-57-2
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性状 Solid
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分子量 720.78
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分子式 C21H41N5O7.5/2H2SO4
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Color White to off-white
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SMILES
NCC1=CC[C@@H](N)[C@](O[C@@H]2[C@@H](N)C[C@@H](NCC)[C@H](O[C@@]3([H])OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)([H])O1.[2.5H2SO4]
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別名
SCH-20569 (sulfate); 硫酸ネチルマイシン
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : 100 mg/mL (138.74 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (69.37 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (278 KB)
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SDS (420 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3874 mL | 6.9369 mL | 13.8739 mL | 34.6846 mL |
| 5 mM | 0.2775 mL | 1.3874 mL | 2.7748 mL | 6.9369 mL | |
| 10 mM | 0.1387 mL | 0.6937 mL | 1.3874 mL | 3.4685 mL | |
| 15 mM | 0.0925 mL | 0.4625 mL | 0.9249 mL | 2.3123 mL | |
| 20 mM | 0.0694 mL | 0.3468 mL | 0.6937 mL | 1.7342 mL | |
| 25 mM | 0.0555 mL | 0.2775 mL | 0.5550 mL | 1.3874 mL | |
| 30 mM | 0.0462 mL | 0.2312 mL | 0.4625 mL | 1.1562 mL | |
| 40 mM | 0.0347 mL | 0.1734 mL | 0.3468 mL | 0.8671 mL | |
| 50 mM | 0.0277 mL | 0.1387 mL | 0.2775 mL | 0.6937 mL | |
| 60 mM | 0.0231 mL | 0.1156 mL | 0.2312 mL | 0.5781 mL | |
| 80 mM | 0.0173 mL | 0.0867 mL | 0.1734 mL | 0.4336 mL | |
| 100 mM | 0.0139 mL | 0.0694 mL | 0.1387 mL | 0.3468 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Netilmicin sulfate 関連分類
HY-A0086 関連分類
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