Arg-Gly-Asp
Based on 11 publication(s) in Google Scholar
RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.60%
- CAS 番号: 99896-85-2
- 分子式: C12H22N6O6
- 分子量:346.34
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保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 RGD
More- Nat Commun. 2024 Apr 18;15(1):3343. [Abstract]
- Smart Med. 2026 Feb 9;5(1):e70029. [Abstract]
- Chem Eng J. 5 February 2022, 135088.
- Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499. [Abstract]
- J Funct Biomater. 2026 Jun 26;17(7):312.
- Cancer Sci. 2020 Aug;111(8):2803-2813. [Abstract]
- Colloid Polym Sci. 2023 Feb 27.
- bioRxiv. 2026 Jul 9:2026.07.08.737105.
- Radiat Med Prot. 2026 Apr 3;7(2):63-72.
- bioRxiv. 2025 Aug 12.
- Mater Sci Forum. 2019, 955: 68-73.
Customer Validation & Images
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Cell Imaging/Staining
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Bio/Physico-chemical Assay
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In Vivo Efficacy Study
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IHC
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Histological Imaging/Staining
生物活性
製品説明
IC50 & Target
Integrin[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Platelet | IC50 |
319 μM
Compound: RGD
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Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
Antiplatelet activity in citrated human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 10 mins at 37 degC by light transmission aggregometry
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[PMID: 25457125] |
体外実験
RGD is the most effective and most often employed peptide sequence for stimulated cell adhesion on synthetic surfaces. There are 24 integrins binding to ECM molecules in a RGD dependent manner: α3β1, α5β1, α8β1, αIIbβ3, αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, and to some extent α2β1 and α4β1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 99896-85-2
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性状 Solid
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分子量 346.34
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分子式 C12H22N6O6
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Color White to off-white
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別名
RGD
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配列
Arg-Gly-Asp
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シーケンスの短縮
RGD
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (11)
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Journal Impact Factor
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Most Recent
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Nat Commun
Mechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation. [Abstract]2024 Apr 18;15(1):3343. PMID: 38637580
RGD purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 18;15(1):3343. [Abstract]
RGD (0.2 mg/mL) was used to immobilize RAW264.7 cells on the hydrogel and minimize cell leakage during operation.
RGD purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 18;15(1):3343. [Abstract]
With or without RGD (0.2 mg/mL) modification, the numbers of RAW264.7 cells in the medium before and after loading and the percentage of cells loaded into the iMASSAGE device were shown.
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Smart Med
LINC00973/DTX3L Axis Promotes Non-Small Cell Lung Cancer Progression and Serves as a Therapeutic Target. [Abstract]2026 Feb 9;5(1):e70029. PMID: 41684454 -
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Int J Biol Macromol
Inhibition of integrin receptors reduces extracellular matrix levels, ameliorating benign prostate hyperplasia. [Abstract]2023 Dec 31;253(Pt 1):126499. PMID: 37659484
RGD purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499. [Abstract]
RGD (1-5 mg; i.v.; 30 d) significantly ameliorated the prostate volume and the prostate weight-to-body weight ratio of testosterone (TP)-induced BPH mice.
RGD purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499. [Abstract]
RGD (1-5 mg; i.v.; 30 d) strikingly increased global succinylation levels in testosterone (TP)-induced BPH mice.
RGD purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499. [Abstract]
RGD (1-5 mg; i.v.; 30 d) therapy significantly ameliorated prostate hyperplasia of testosterone (TP)-induced BPH mice, as evidenced by the absence of morphological abnormalities such as excessive proliferation in the glandular epithelium, focal intraluminal papillary folds, and secretion-filled distended ducts.
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Cancer Sci
Death-associated protein kinase 1 suppresses hepatocellular carcinoma cell migration and invasion by upregulation of DEAD-box helicase 20. [Abstract]2020 Aug;111(8):2803-2813. PMID: 32449268 -
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溶剤 & 溶解度
体外:
H2O : 10 mg/mL (28.87 mM; Need ultrasonic)
DMSO : 1.94 mg/mL (5.60 mM; ultrasonic and adjust pH to 3 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (394 KB)
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- Italian - IT (394 KB)
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- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.8873 mL | 14.4367 mL | 28.8734 mL | 72.1834 mL |
| 5 mM | 0.5775 mL | 2.8873 mL | 5.7747 mL | 14.4367 mL | |
| H2O | 10 mM | 0.2887 mL | 1.4437 mL | 2.8873 mL | 7.2183 mL |
| 15 mM | 0.1925 mL | 0.9624 mL | 1.9249 mL | 4.8122 mL | |
| 20 mM | 0.1444 mL | 0.7218 mL | 1.4437 mL | 3.6092 mL | |
| 25 mM | 0.1155 mL | 0.5775 mL | 1.1549 mL | 2.8873 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
RGD 関連分類
HY-P0278 関連分類
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