Rutin (hydrate)
Based on 35 publication(s) in Google Scholar
Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.33%
- CAS 番号: 207671-50-9
- 分子式: C27H3O16.36/5H2O
- 分子量:713.04
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Rutin hydrate
More- Signal Transduct Target Ther. 2026 Mar 26;11(1):113. [Abstract]
- Neuron. 2025 Jul 23;113(14):2280-2296.e8. [Abstract]
- Adv Sci (Weinh). 2022 Dec;9(34):e2203088. [Abstract]
- Cell Death Differ. 2025 Jun;32(6):1041-1057. [Abstract]
- Phytomedicine. 2025 Sep 15:148:157267. [Abstract]
- Phytomedicine. 2023 Apr:112:154700. [Abstract]
- Food Chem. 2025 Dec 30:497:146992. [Abstract]
- Food Chem. 2025 Oct 15:489:144992. [Abstract]
- Food Chem. 2023 Mar 30;405(Pt A):134807. [Abstract]
- Food Chem. 2022 May 1:375:131872. [Abstract]
- Food Res Int. 2024 Oct:193:114812. [Abstract]
- Antioxidants (Basel). 2026 May 29;15(6):688. [Abstract]
- Antioxidants (Basel). 2023 Nov 7;12(11):1974. [Abstract]
- Biochem Pharmacol. 2026 Oct:252:118212.
- Ind Crops Prod. 2025 Dec 11;239:122458.
- Food Funct. 2025 Oct 27;16(21):8548-8563. [Abstract]
- Eur J Pharmacol. 2025 Jul 5:998:177536. [Abstract]
- Int Immunopharmacol. 2026 Mar 1:172:116231. [Abstract]
- ACS Omega. 2024 Feb 28;9(10):11870-11882. [Abstract]
- Metabolites. 2025 Dec 23;16(1):12.
- Metabolites. 2025 Dec 23;16(1):12. [Abstract]
- iScience. 2023 Sep 9;26(10):107866. [Abstract]
- Biology (Basel). 2024 Aug 29;13(9):676. [Abstract]
- Polym Bull (Berl). 2026 Mar 26;83(6):314.
- Neurotoxicology. 2024 Sep:104:1-10. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- Hum Mutat. 2026 Apr 2:2026:4033506. [Abstract]
- Arch Endocrinol Metab. 2025 Aug 20;69(4):e240410. [Abstract]
- Lett Drug Des Discov. 2026 Feb 11.
- Pharmacogn Mag. 2023 Oct 12.
- SSRN. 2026 Jun 21.
- SSRN. 2025 Oct 6.
- Eur Rev Med Pharmacol Sci. 2025 Sep;29(9):425-433. [Abstract]
- Regulatory Research and Medicine Evaluation. 2025.
- SSRN. 2025 Mar 20.
Customer Validation & Images
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Histological Imaging/Staining
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ELISA
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 207671-50-9
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性状 Solid
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分子量 713.04
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分子式 C27H3O16.36/5H2O
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Color Light yellow to yellow
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SMILES
O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)O2)O)O)O)=C(C4=CC=C(O)C(O)=C4)OC5=CC(O)=CC(O)=C15.O.[36/5]
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別名
ルチン 水和物; Rutoside (hydrate); Quercetin 3-O-rutinoside (hydrate)
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (35)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer. [Abstract]2026 Mar 26;11(1):113. PMID: 41888107 -
Neuron
Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury. [Abstract]2025 Jul 23;113(14):2280-2296.e8. PMID: 40328251 -
Adv Sci (Weinh)
SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus. [Abstract]2022 Dec;9(34):e2203088. PMID: 36257906 -
Cell Death Differ
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4. [Abstract]2025 Jun;32(6):1041-1057. PMID: 39875520 -
Phytomedicine
Combined transcriptomics and network pharmacology to elucidate the mechanisms of rutin in treating ischemic stroke rat. [Abstract]2025 Sep 15:148:157267. PMID: 40975038
Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]
Rutin (80 mg/kg, q.d., 3 days) reduces pathological damage. Scale bar = 50 μm, n = 6 per group.
Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]
Effect of rutin (80 mg/kg, q.d., 3 days) on NF-κB/NLRP3 signaling and cell localization in tMCAO rats. (A-H) Western blot analysis of the protein expression level of NF-κB p65, NLRP3, Caspase-1, GSDMD in MCAO/R rats brain tissues and grayscale scanning analysis. Scale bar = 20 μm. n = 3 per group.
Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]
Effect of rutin (80 mg/kg, q.d., 3 days) on NF-κB/NLRP3 signaling and cell localization in tMCAO rats. ELISA analysis of IL-1β, IL-18, IL-6, TNF-α levels in serum. Scale bar = 20 μm. n = 3 per group.
Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]
Effect of rutin (80 mg/kg, q.d., 3 days) on NF-κB/NLRP3 signaling and cell localization in tMCAO rats. Representative immunofluorescence staining pictures of NLRP3 in brain tissues. Scale bar = 20 μm. n = 3 per group.
Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]
Effect of rutin (40 μM, 24 h) on OGD/R-induced primary astrocyte during reperfusion. Representative immunofluorescence staining pictures of NLRP3, GSDMD in OGD/R-induced primary astrocyte. Scale bar = 20 μm, n = 3 per group.
Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]
Effect of rutin (5, 10, 20, and 40 μM, 24 h) on OGD/R-induced primary astrocyte. Cell viability was determined with CCK-8 kit.
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Phytomedicine
Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K/AKT/mTOR pathway in diabetic kidney disease. [Abstract]2023 Apr:112:154700. PMID: 36774842 -
Food Chem
Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]2025 Dec 30:497:146992. PMID: 41285060 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530 -
Food Chem
Discovery of novel ascorbic acid derivatives and other metabolites in fruit of Rosa roxburghii Tratt through untargeted metabolomics and feature-based molecular networking. [Abstract]2023 Mar 30;405(Pt A):134807. PMID: 36370576 -
Food Chem
New insights into the influences of baking and storage on the nonvolatile compounds in oolong tea: A nontargeted and targeted metabolomics study. [Abstract]2022 May 1:375:131872. PMID: 34953237 -
Food Res Int
2024 Oct:193:114812. PMID: 39160037 -
Antioxidants (Basel)
Bioactive Extracts and Constituents from Taraxacum mongolicum: Antioxidant, Anti-Inflammatory, Enzyme-Inhibitory, and Molecular Docking Studies. [Abstract]2026 May 29;15(6):688. PMID: 42351994 -
Antioxidants (Basel)
Phenolic Profile and Bioactivity Changes of Lotus Seedpod and Litchi Pericarp Procyanidins: Effect of Probiotic Bacteria Biotransformation. [Abstract]2023 Nov 7;12(11):1974. PMID: 38001827 -
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Food Funct
Blackthorn juice from central Italy exhibits selective anticancer activity by inducing apoptosis and autophagy in gastric carcinoma cells. [Abstract]2025 Oct 27;16(21):8548-8563. PMID: 41085359 -
Eur J Pharmacol
Rutin protects the pancreas from inflammatory injury and oncogene-driven tumorigenesis by inhibiting acinar to ductal metaplasia. [Abstract]2025 Jul 5:998:177536. PMID: 40120793 -
Int Immunopharmacol
Rutin ameliorates hepatic ischemia-reperfusion injury by targeting CD36 to suppress hepatocyte ferroptosis. [Abstract]2026 Mar 1:172:116231. PMID: 41576568 -
ACS Omega
Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]2024 Feb 28;9(10):11870-11882. PMID: 38496939 -
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Metabolites
Rutin Maintains the Thermogenic Phenotype of Beige Adipocytes and Concomitantly Suppresses Mitophagy Against Obesity in HFD Mice. [Abstract]2025 Dec 23;16(1):12. PMID: 41590620 -
iScience
Rutin alleviates ventilator-induced lung injury by inhibiting NLRP3 inflammasome activation. [Abstract]2023 Sep 9;26(10):107866. PMID: 37817937 -
Biology (Basel)
Antibacterial, Antibiofilm, and Wound Healing Activities of Rutin and Quercetin and Their Interaction with Gentamicin on Excision Wounds in Diabetic Mice. [Abstract]2024 Aug 29;13(9):676. PMID: 39336103 -
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Neurotoxicology
Rutin alleviates Pb-induced oxidative stress, inflammation and cell death via activating Nrf2/ARE system in SH-SY5Y cells. [Abstract]2024 Sep:104:1-10. PMID: 39032614 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Hum Mutat
SELL Marks an Effector-Deficient CD8+ T Cell Subset That Promotes Intracerebral Hemorrhage and Responds to Rutin Therapy. [Abstract]2026 Apr 2:2026:4033506. PMID: 41937927 -
Arch Endocrinol Metab
miR-590-5p mediates mitochondrial respiration, proliferation, and apoptosis in thyroid carcinoma cells via fibroblast growth factor receptor substrate 2. [Abstract]2025 Aug 20;69(4):e240410. PMID: 40834280 -
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Eur Rev Med Pharmacol Sci
Mulberry leaf extracts and quercetin glycosides promote glycogen accumulation in astrocytes. [Abstract]2025 Sep;29(9):425-433. PMID: 41059752 -
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溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (140.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.51 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.51 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 1% CMC-Na/saline water
Solubility: 3.33 mg/mL (4.67 mM); Suspended solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
プロトコル
Animal Administration[1]
Rats[1]
(1) A control group receives of 0.01 g/mL carboxymethylcellulose (CMC) dissolved in distilled water; (2) α-tocopherol acetate treated group: control rats receive α-tocopherol (120 IU/rat) diluted in 0.1 mL of coconut oil; (3) Rutin hydrate treated control group (control + Rutin hydrate): control rats receive Rutin hydrate (100 mg/kg); (4) CdCl2 intoxicated group receives CdCl2 at a final dose of 5 mg/kg to induce neurotoxicity; (5) CdCl2 + Rutin hydrate treated group (CdCl2 + Rutin hydrate) receives CdCl2 (5 mg/kg) and receives a coincided dose of Rutin hydrate (100 mg/kg body weight); (6) CdCl2 + Rutin hydrate + α-tocopherol acetate-treated group receives CdCl2 (5 mg/kg) and receives concomitant dose of Rutin hydrate (100 mg/kg) in conjugation with α-tocopherol acetate (120 IU/rat) that is diluted in 0.1 mL of coconut oil. All treatments are given by orogastric gavage with a polyethylene catheter PE 190 daily for 30 days[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
純度とドキュメンテーション
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データシート (286 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305-312. [Content Brief]
[2]. Habtemariam S. Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873. [Content Brief]
[3]. Xu PX, et al. Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014;264:173-180. [Content Brief]
[4]. Abdel-Aleem GA, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling. Arch Physiol Biochem. 2018;124(4):367-377. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4024 mL | 7.0122 mL | 14.0245 mL | 35.0611 mL |
| 5 mM | 0.2805 mL | 1.4024 mL | 2.8049 mL | 7.0122 mL | |
| 10 mM | 0.1402 mL | 0.7012 mL | 1.4024 mL | 3.5061 mL | |
| 15 mM | 0.0935 mL | 0.4675 mL | 0.9350 mL | 2.3374 mL | |
| 20 mM | 0.0701 mL | 0.3506 mL | 0.7012 mL | 1.7531 mL | |
| 25 mM | 0.0561 mL | 0.2805 mL | 0.5610 mL | 1.4024 mL | |
| 30 mM | 0.0467 mL | 0.2337 mL | 0.4675 mL | 1.1687 mL | |
| 40 mM | 0.0351 mL | 0.1753 mL | 0.3506 mL | 0.8765 mL | |
| 50 mM | 0.0280 mL | 0.1402 mL | 0.2805 mL | 0.7012 mL | |
| 60 mM | 0.0234 mL | 0.1169 mL | 0.2337 mL | 0.5844 mL | |
| 80 mM | 0.0175 mL | 0.0877 mL | 0.1753 mL | 0.4383 mL | |
| 100 mM | 0.0140 mL | 0.0701 mL | 0.1402 mL | 0.3506 mL |
Rutin hydrate 関連分類
HY-N0148A 関連分類
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