TMV
Tobacco mosaic virus
Tobacco mosaic virus (TMV) is named for one of the first plants in which it was found in the 1886. TMV can infect well over 350 different species of plants, many of which are favorites in home gardens such as tomatoes and potatoes. However TMV exclusively infects plants and is completely harmless for mammals. The rod-shaped virus particles (virions) of TMV measure about 300 nm x 15 nm. A single TMV particle is composed of 2,130 copies of the coat protein (CP) that envelope the RNA molecule of about 6,400 nucleotides. This single-stranded RNA encodes four genes: two replicase-associated proteins that are directly translated from the TMV RNA, and the movement protein and a coat protein that are translated from subgenomic RNAs. TMV is the textbook example for self-assembly. The assembly of the CPs (with or without RNA) to viruslike tubes is becoming an attractive way for nanoscale construction.
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TMV 関連製品 (37)
関連製品 (37)
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- DL-Serine (DL-Serine)
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trans-3-(3-Pyridyl)acrylic acid
0 Imagestrans-3-(3-Pyridyl) acrylic acid is an unsaturated carboxylic acid and synthetic building block, which serves as a synthetic precursor of 3-(3-pyridyl) propanoic acid. trans-3-(3-Pyridyl) acrylic acid can be used to prepare dual mutant IDH1/NAMPT inhibitors and PGE2 antagonist analogs. In addition, trans-3-(3-Pyridyl) acrylic acid exhibits antiviral activity against tobacco mosaic virus (TMV).
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(-)-Cryptopleurine
0 Images(–)-Cryptopleurine is an alkaloid that has been found in Lauraceae and has diverse biological activities. It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells (IC50=3 nM for all).2 (–)-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay (IC50=8.7 nM).3 (–)-Cryptopleurine (500 μg/mL) prevents lesion formation in tobacco (N. tabacum) plants infected with tobacco mosaic virus (TMV). It also inhibits protein synthesis by yeast and mammalian ribosomes.
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Meliatoosenin N
0 Images製品番号: HY-N18141CAS 番号: 1355997-07-7Meliatoosenin N is a limonoid compound. Meliatoosenin N inhibits the replication of tobacco mosaic virus in vitro.
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Yadanzioside I
0 Images製品番号: HY-N7532CAS 番号: 99132-95-3Yadanzioside I is a potent anti-tobacco mosaic virus (TMV) quassinoid with an IC50 of 4.22 μM.
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Lobaric acid
0 ImagesLobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC50=97.9 μM) and inhibits cancer cell proliferation (EC50 of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC50=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).
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(±)-Phrymarolin II
0 Images製品番号: HY-N10110CAS 番号: 23720-86-7(±)-Phrymarolin II is a promising new class of plant virus (tobacco mosaic virus) inhibitors.
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TMV-IN-10
0 Images製品番号: HY-162807CAS 番号: 443749-05-1TMV-IN-10 (compound 4h) is an arecoline derivative with anti-tobacco mosaic virus (TMV) activity (EC50=146 µg/mL). TMV-IN-10 can be used in research on controlling crop pests and diseases and improving crop yields by acting on the viral coat protein (CP) to cause viral fragmentation.
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7-Deoxy-trans-dihydronarciclasine
0 Images製品番号: HY-N12249CAS 番号: 145987-74-27-Deoxy-trans-dihydronarciclasine, an alkaloid, is a tobacco mosaic virus (TMV) inhibitor (IC50: 1.80 μM). 7-Deoxy-trans-dihydronarciclasine is an anti-neuroinflammatory agent. 7-Deoxy-trans-dihydronarciclasine decreases the Aβ and APP levels in the cerebral cortex of Tg2576 mice.
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TMV-IN-5
0 Images製品番号: HY-155044CAS 番号: 1207318-92-0TMV-IN-5 (compound 1a) is an anti-plant virus/fungal agent. TMV-IN-5 inhibits viral assembly by binding to tobacco mosaic virus (TMV) CP. TMV-IN-5 can be used in the development of pesticides.
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TMV-IN-14
0 Images製品番号: HY-169425CAS 番号: 3051649-38-5TMV-IN-14 (compound A21) is an agrochemical agent withstrongly interaction between with TMV coat protein through various interactions.
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