テオブロミン
Based on 1 publication(s) in Google Scholar
Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.60%
- CAS 番号: 83-67-0
- 分子式: C7H8N4O2
- 分子量:180.17
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Theobromine
MoreAdenosine Receptor アイソフォーム固有の製品をすべて表示
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
AR1[1]
体外実験
Theobromine, at concentrations above 25 μM, decreases lipid accumulation in these cells. Cell viability is not affected by Theobromine. Theobromine, at concentrations above 25 μM, suppresses protein expression of PPARγ, C/EBPα and adipogenic genes. The mRNA levels of these genes are also decreased by Theobromine[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 83-67-0
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性状 Solid
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分子量 180.17
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分子式 C7H8N4O2
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Color White to off-white
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SMILES
O=C(N1)N(C)C2=C(N(C)C=N2)C1=O
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別名
Theobromine; 3,7-Dimethylxanthine; 3,7-ジメチルキサンチン
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Microbiol Immunol
2023 Sep;67(9):404-412. PMID: 37415325
溶剤 & 溶解度
体外:
0.5 M NaOH : 20 mg/mL (111.01 mM; Need ultrasonic)
DMSO : 1.1 mg/mL (6.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (293 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Mitani T, et al. Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein β degradation by adenosine receptor A1. [Content Brief]
[2]. Martín-Peláez S, et al. Effect of cocoa's theobromine on intestinal microbiota of rats. Mol Nutr Food Res. 2017 Oct;61(10). [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 0.5 M NaOH | 1 mM | 5.5503 mL | 27.7516 mL | 55.5031 mL | 138.7578 mL |
| 5 mM | 1.1101 mL | 5.5503 mL | 11.1006 mL | 27.7516 mL | |
| 0.5 M NaOH | 10 mM | 0.5550 mL | 2.7752 mL | 5.5503 mL | 13.8758 mL |
| 15 mM | 0.3700 mL | 1.8501 mL | 3.7002 mL | 9.2505 mL | |
| 20 mM | 0.2775 mL | 1.3876 mL | 2.7752 mL | 6.9379 mL | |
| 25 mM | 0.2220 mL | 1.1101 mL | 2.2201 mL | 5.5503 mL | |
| 30 mM | 0.1850 mL | 0.9251 mL | 1.8501 mL | 4.6253 mL | |
| 40 mM | 0.1388 mL | 0.6938 mL | 1.3876 mL | 3.4689 mL | |
| 50 mM | 0.1110 mL | 0.5550 mL | 1.1101 mL | 2.7752 mL | |
| 60 mM | 0.0925 mL | 0.4625 mL | 0.9251 mL | 2.3126 mL | |
| 80 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7345 mL | |
| 100 mM | 0.0555 mL | 0.2775 mL | 0.5550 mL | 1.3876 mL |
Theobromine 関連分類
HY-N0138 関連分類
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