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Afimkibart (WT IgG1)

(別名: PF-06480605 (WT IgG1); RVT-3101 (WT IgG1))
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Afimkibart (PF-06480605; RVT-3101) is a fully human monoclonal antibody that selectively inhibits trimeric tumor necrosis factor-like ligand 1A (TL1A). Afimkibart neutralizes active trimeric TL1A, blocks TL1A-induced signaling pathways. Afimkibart inhibits NF-κB activation and IFN-γ production. Afimkibart can be used for the research of inflammatory bowel disease.

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  • 純度: 99.59%
  • CAS 番号: 2911580-96-4
  • 分子量:146.54 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Afimkibart (WT IgG1)
  • Experimental Validation Results for Afimkibart (WT IgG1)
  • Experimental Validation Results for Afimkibart (WT IgG1)
  • Afimkibart (WT IgG1) Chemical Structure
    Afimkibart (WT IgG1) 構造式
CAS 番号: 2911580-96-4
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Assay Types
  • 1/16

    IgG1-kappa

  • 1/16

    Immobilized TL1A/TNFSF15 Trimer Protein, Human can bind Afimkibart. The EC50 for this effect is 8.563 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 HT-29 cells with Afimkibart (HY-P990876, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa, Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Afimkibart (WT IgG1) Chemical Structure
    1/16
  • Afimkibart (WT IgG1)
  • Immobilized TL1A/TNFSF15 Trimer Protein, Human can bind Afimkibart. The EC50 for this effect is 8.563 ng/mL.
  • Flow cytometric analysis of 1.5X106 HT-29 cells with Afimkibart (HY-P990876, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa, Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa