Anonaine
Based on 1 Customer Validation
Anonaine is an antiparasitic agent. Anonaine also is a glutathione S-transferase (GST) inhibitor.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.0%
- CAS 番号: 1862-41-5
- 分子式: C17H15NO2
- 分子量:265.31
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | ED50 |
4.2 μg/mL
Compound: 3
|
Cytotoxicity against human A431 cells after 3 days by SRB assay
Cytotoxicity against human A431 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| AGS | IC50 |
8.6 μM
Compound: 5
|
Cytotoxicity against human AGS cells by MTS colorimetric assay
Cytotoxicity against human AGS cells by MTS colorimetric assay
|
[PMID: 11087586] |
| DLD-1 | IC50 |
28.9 μM
Compound: 5
|
Cytotoxicity against human DLD1 cells by MTS colorimetric assay
Cytotoxicity against human DLD1 cells by MTS colorimetric assay
|
[PMID: 11087586] |
| HeLa | IC50 |
24.8 μg/mL
Compound: Anonaine, III
|
Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
|
[PMID: 18295494] |
| Hepatocyte | IC50 |
70.3 μg/mL
Compound: Anonaine, III
|
Cytotoxicity against Sprague-Dawley rat primary hepatocytes after 24 hrs by MTT assay
Cytotoxicity against Sprague-Dawley rat primary hepatocytes after 24 hrs by MTT assay
|
[PMID: 18295494] |
| HepG2 | IC50 |
20.8 μM
Compound: 5
|
Cytotoxicity against human HepG2 cells by MTS colorimetric assay
Cytotoxicity against human HepG2 cells by MTS colorimetric assay
|
[PMID: 11087586] |
| HepG2 | IC50 |
33.5 μg/mL
Compound: Anonaine, III
|
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
|
[PMID: 18295494] |
| HT-1080 | ED50 |
2.4 μg/mL
Compound: 3
|
Cytotoxicity against human HT1080 cells after 3 days by SRB assay
Cytotoxicity against human HT1080 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| KB | ED50 |
2.6 μg/mL
Compound: 3
|
Cytotoxicity against human KB cells after 3 days by SRB assay
Cytotoxicity against human KB cells after 3 days by SRB assay
|
[PMID: 8254346] |
| KB-V1 | ED50 |
1.8 μg/mL
Compound: 3
|
Cytotoxicity against vinblastine-resistant human KBV1 cells after 3 days by SRB assay
Cytotoxicity against vinblastine-resistant human KBV1 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| LNCaP | ED50 |
2.9 μg/mL
Compound: 3
|
Cytotoxicity against human LNCAP cells after 3 days by SRB assay
Cytotoxicity against human LNCAP cells after 3 days by SRB assay
|
[PMID: 8254346] |
| P388 | ED50 |
>5 μg/mL
Compound: 3
|
Cytotoxicity against mouse P388 cells after 3 days by SRB assay
Cytotoxicity against mouse P388 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| SK-MEL-2 | ED50 |
15.8 μg/mL
Compound: 3
|
Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| U-373MG ATCC | ED50 |
1.5 μg/mL
Compound: 3
|
Cytotoxicity against human U373 cells after 3 days by SRB assay
Cytotoxicity against human U373 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| ZR-75-1 | ED50 |
2.7 μg/mL
Compound: 3
|
Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay
Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay
|
[PMID: 8254346] |
化学情報
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CAS 番号 1862-41-5
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性状 Solid
-
分子量 265.31
-
分子式 C17H15NO2
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Color Brown to black
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SMILES
[H][C@@]1(NCC2)CC3=CC=CC=C3C4=C1C2=CC5=C4OCO5
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)