Anthramycin
Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potent antibiotic. Anthramycin has potent antitumor activity. Anthramycin can act as an potent antagonist of cholecystokinin in the central nervous system in mice.
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- CAS 番号: 4803-27-4
- 分子式: C16H17N3O4
- 分子量:315.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Antibiotic アイソフォーム固有の製品をすべて表示
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生物活性
ANT is delivered through the skin for PG (propylene glycol), TC (Transcutol P) and PGML (propylene glycol monolaurate) with the active “tracking” the skin penetration of both PG and TC[1].
Anthramycin (10-1000 μM) dose not affect the ATPase activity of heart mitochondria[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anthramycin (0.1-0.5 mg/kg, SC, daily for 8 days) has no effect on mitochondrial metabolism of the rat heart[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male ddY mice (20 ± 2 g, 12-14 each group)[2]
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Dosage:0, 0.3, and 0.5 mg/kg
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Administration:IP, once, 10 min before the intracisternal (i.c.) injection of CCK
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Result:Significantly inhibited CCK-induced increase in the pain threshold in a dose-dependent manner. Almost completely suppressed the antinociceptive effects of CCK at the higher dose (0.5 mg/kg).
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Animal Model:Female CFN Gif rats (140-180 g)[3]
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Dosage:0.1 mg/kg, 0.25 mg/kg, and 0.5 mg/kg
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Administration:SC, daily for 8 days
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Result:Recorded no differences between anthramycin- and DMSO-treated rats with respect to P/O ratios, respiration rates, and ATPase activity of heart mitochondria.
化学情報
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CAS 番号 4803-27-4
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分子量 315.32
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分子式 C16H17N3O4
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SMILES
O=C1N2[C@@]([C@H](NC3=C(O)C(C)=CC=C31)O)([H])CC(/C=C/C(N)=O)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Haque T, et al. Topical delivery of anthramycin II. Influence of binary and ternary solvent systems. Eur J Pharm Sci. 2018 Aug 30;121:59-64. [Content Brief]
[2]. Kubota K, et al. Cholecystokinin antagonism by anthramycin, a benzodiazepine antibiotic, in the central nervous system in mice. Brain Res. 1989 Apr 17;485(1):62-6. [Content Brief]
[3]. Cargill C, et al. Effects of daunomycin and anthramycin on electrocardiogram and mitochondrial metabolism of the rat heart. J Natl Cancer Inst. 1974 Aug;53(2):481-6. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anthramycin 関連分類
HY-150036 関連分類
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