Asukamycin
Based on 1 Customer Validation
Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.0%
- CAS 番号: 61116-33-4
- 分子式: C31H34N2O7
- 分子量:546.61
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Antibiotic アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCC38 | EC50 |
4.5 μM
Compound: Asukamycin
|
Antiproliferative activity against human HCC38 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Antiproliferative activity against human HCC38 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
|
[PMID: 37984298] |
| MDA-MB-231 | EC50 |
13.8 μM
Compound: Asukamycin
|
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
|
[PMID: 37984298] |
体外実験
Asukamycin (1-50 μM; 24 h) in a concentration-dependent manner reduces viability of five different human cell lines with IC50 of 1-5 μM[1].
Asukamycin (50 μM; 24 and 72 h; THP-1 cells) causes a significant increase in intracellular caspase 8 and caspase 3 activity[1].
Asukamycin (0-100 mcg/mL; bacteria, 18 h; fungus, 72 h) has antimicrobial activity. Asukamycin inhibits the growth of Gram-positive bacteria within a concentration range of 0.78-12.5 mcg/mL and inhibits the growth of Trichophyton mentagrophytes at a concentration of 25 mcg/ mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human myeloid THP-1, HL-60, U-118 MG, U-87 MG and U-937 cells
-
Concentration:1-50 μM
-
Incubation Time:24 hours
-
Result:Reduced viability of five different cell lines in a concentration-dependent manner.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Mice[2]
-
Dosage:0-450 mg/kg
-
Administration:Intraperitoneal injection
-
Result:Had no effect on mice when administered by 450 mg/kg and the acute toxicity (LD50) was 48.5 mg/kg by intraperitoneal injection.
化学情報
-
CAS 番号 61116-33-4
-
性状 Solid
-
分子量 546.61
-
分子式 C31H34N2O7
-
Color Light yellow to yellow
-
SMILES
O=C1[C@@H]2[C@H]([C@@](O)(C=C1NC(/C=C/C=C/C=C/C3CCCCC3)=O)/C=C/C=C/C=C/C(NC4=C(CCC4=O)O)=O)O2
-
Structure Classification
-
Initial Source
Streptomyces nodosus subsp. asukaensis.
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
-
データシート (268 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Shipley PR, et, al. Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis. Int J Mol Med. 2009 Nov;24(5):711-5. [Content Brief]
[2]. Omura S, et, al. A new antibiotic,, asukamycin, produced by Streptomyces. J Antibiot (Tokyo). 1976 Sep;29(9):876-81. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Asukamycin 関連分類
HY-118893 関連分類
Powered by Bioz