Bersanlimab
Based on 1 Customer Validation
Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.85%
- CAS 番号: 1987854-08-9
- 分子量:144.22 kDa
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
Human IgG1 lambda2
Human
ICAM1/CD54
BI-505 (1 ng/mL-1000 μg/mL) dose-dependently induces programmed cell death (PCD) in ICAM-1-expressing Ramos, Raji, and Daudi lymphoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:SCID mice injected with ARH-77 cells[1]
-
Dosage:20 mg/kg
-
Administration:i.p.; twice-weekly; for 21 days
-
Result:Significantly reduced tumor growth and prolonged animal survival.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Human IgG1 lambda2
ELISA, FACS, Functional assay
-
Immobilized ICAM-1/CD54 Protein, Human (HEK293, His, HY-P72621) can bind Bersanlimab. The EC50 for this effect is 0.4293 ng/mL. -
Flow Cytometry analysis of Raji cells labelling ICAM1/CD54 (red) with Bersanlimab (anti-ICAM1/CD54) (HY-P99473). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 lambda2 (HY-P990096). Black-Unlabelled control, cells without incubation with primary antibody.
化学情報
-
CAS 番号 1987854-08-9
-
性状 Liquid
-
分子量 144.22 kDa
-
Color Colorless to light yellow
-
SMILES
[Bersanlimab]
-
別名
BI-505
-
輸送条件
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
-
データシート (256 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)