Ceramide 3
Based on 1 Customer Validation
Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 34354-88-6
- 分子式: C36H73NO4
- 分子量:583.97
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (male, 5 weeks old, 20-22 g)[1]
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Dosage:20 mg/kg; 50 mg/kg
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Administration:p.o.; single dose 1 hour prior to histamine challenge
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Result:Reduced histamine-induced scratching behavior frequency (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Inhibited histamine-induced IL-4 protein expression (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Inhibited histamine-induced TNF-α protein expression (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Reduced histamine-induced vascular permeability (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Reduced histamine-induced skin inflammation (epidermal hyperplasia and inflammatory cell infiltration) at 20 mg/kg.
Reduced histamine-induced scratching behavior frequency by 67% at 50 mg/kg.
Inhibited histamine-induced IL-4 protein expression by 75% at 50 mg/kg.
Inhibited histamine-induced TNF-α protein expression by 88% at 50 mg/kg.
Reduced histamine-induced vascular permeability by 51% at 50 mg/kg.
Reduced histamine-induced skin inflammation (epidermal hyperplasia and inflammatory cell infiltration) at 50 mg/kg.
Inhibited histamine-induced activation of transcription factors NF-κB (phospho-p65) and c-jun (phospho-c-jun) at both 20 mg/kg and 50 mg/kg.
化学情報
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CAS 番号 34354-88-6
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性状 Solid
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分子量 583.97
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分子式 C36H73NO4
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Color White to off-white
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SMILES
CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(CCCCCCCCCCCCCCCCC)=O
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別名
N-Stearoyl phytosphingosine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
Methanol : 1 mg/mL (1.71 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (267 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ryu KR, et al. Anti-scratching behavioral effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice. Lipids. 2010;45(7):613-618. [Content Brief]
[3]. Kucharekova M, et al. Effect of a lipid-rich emollient containing ceramide 3 in experimentally induced skin barrier dysfunction. Contact Dermatitis. 2002;46(6):331-338. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Methanol | 1 mM | 1.7124 mL | 8.5621 mL | 17.1242 mL | 42.8104 mL |
Ceramide 3 関連分類
HY-141582 関連分類
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