Chrysomycin A
Based on 1 Customer Validation
Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 82196-88-1
- 分子式: C28H28O9
- 分子量:508.52
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保管条件:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Chrysomycin A (0.2-1.8 μM; 48 h) has anti-glioblastoma efficacy, and inhibits cell viability in U251 and U87-MG human glioblastoma, as well as migration and invasion[1].
Chrysomycin A (0.2-1.8 μM; 48 h) inhibits Akt/GSK-3β/β-Catenin signaling pathway in U251 and U87-MG cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U251 and U87-MG human glioblastoma
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Concentration:0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
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Incubation Time:48 hours
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Result:Inhibited U251 and U87-MG with 0.475 μM and 1.77 μM, respectively.
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Cell Line:U251 and U87-MG human glioblastoma
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Concentration:0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
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Incubation Time:48 hours
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Result:Significantly downregulated the expression of slug and MMP2.
Significantly decreased the protein expression of PI3K-p85, p-PI3K-p85, Akt and p-Akt, as well as c-Myc, cyclin D1.
化学情報
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CAS 番号 82196-88-1
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性状 Solid
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分子量 508.52
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分子式 C28H28O9
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Color Light yellow to yellow
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SMILES
O=C1C2=CC(C=C)=CC(OC)=C2C3=CC(OC)=C4C(O)=CC=C([C@H]5[C@@H]([C@]([C@H]([C@@H](C)O5)O)(C)O)O)C4=C3O1
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別名
Chr-A
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Initial Source
marine-derived strain Streptomyces sp. 891
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
純度とドキュメンテーション
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データシート (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Chrysomycin A 関連分類
HY-126771 関連分類
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