Tagmokitug
Based on 1 Customer Validation
Tagmokitug (CHS-114; SRF-114) is a fully human IgG1 antibody targeting CCR8. Tagmokitug selectively binds to human CCR8 (Kd = 502 pM) and mediates the death of CCR8-expressing cells via antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis. Tagmokitug selectively eliminates intratumoral regulatory T cells, induces tumor growth inhibition, remodels the tumor immune microenvironment, and promotes the differentiation of cytotoxic CD8+ T cell subsets. Tagmokitug can be used for the research of solid tumors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.90%
- CAS 番号: 3024486-14-1
- 分子量:144.12 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Human IgG1 lambda2
Human
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CCR8 502 pM (Kd) |
Tagmokitug (4 h) potently induces NK cell-mediated ADCC against Raji-huCCR8 cells, with an EC50 of 2 ng/mL[1].
Tagmokitug (3 h) potently induces macrophage-mediated antibody-dependent cellular phagocytosis (ADCP) against Raji-huCCR8 cells, with an EC50 of 13.5 ng/mL[1].
Tagmokitug (overnight treatment) selectively eliminates intratumoral regulatory T cells (Tregs) in co-culture systems of activated NK cells with dissociated tumor cells from primary renal cell carcinoma (RCC) and colorectal cancer (CRC), while preserving conventional CD4+ and CD8+ T cells, and activates NK cells and monocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-lambda
ELISA, FACS, Functional assay
化学情報
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CAS 番号 3024486-14-1
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性状 Liquid
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分子量 144.12 kDa
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Color Colorless to light yellow
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SMILES
[Tagmokitug]
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別名
CHS-114; SRF-114
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Tagmokitug 関連分類
HY-P991061 関連分類
Powered by Bioz
- Tagmokitug
- 3024486-14-1
- CHS-114
- SRF-114
- CHS114
- CHS 114
- SRF114
- SRF 114
- SRF-114
- CCR
- solid tumors
- antibody-dependent cellular phagocytosis
- effector T cells
- cytotoxic CD8+ T cells
- HEK 293T cells
- antibody-dependent cellular cytotoxicity
- human CCR8
- tumor-immune microenvironment
- CCR8-expressing cells
- intratumoral regulatory T cells
- Inhibitor
- inhibitor
- inhibit