Divaricatol
Divaricatol is an orally ative chromone natural product and an active component in Saposhnikovia divaricata. Divaricatol reduces the release of pro-inflammatory cytokines and restores immune homeostasis by stably binding to 5KIR (a target of the TNF/IL-17 pathway). Divaricatol exerts analgesic effects in mouse models. Divaricatol can be used in the research of pain, diarrhea-predominant irritable bowel syndrome (IBS-D) and qi deficiency syndrome.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 331433-08-0
- 分子式: C17H18O7
- 分子量:334.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ddy (Male, 4 weeks old, 24–36 g, acetic acid-induced writhing model)[1]
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Dosage:1, 5 mg/kg
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Administration:p.o.; single dose
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Result:Showed potent analgesic effect at oral doses of 1 and 5 mg/kg.
化学情報
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CAS 番号 331433-08-0
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分子量 334.32
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分子式 C17H18O7
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SMILES
OC1=C2C(OC(C)([C@H](C2)OC(C)=O)C)=CC3=C1C(C=C(O3)CO)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001;49(2):154-160. [Content Brief]
[2]. Yu D, et al. Deciphering the microbiological mechanism of Tongxie Yaofang in treating IBS-D: a multimodal mechanistic study in mice integrating network pharmacology, computational simulation, and 16S rRNA sequencing. Exp Biol Med (Maywood). 2025;250:10725. Published 2025 Oct 3. [Content Brief]
[3]. Zhao Z, et al. Integration of serum metabolomics and network pharmacology reveals the immunoenhancing mechanisms of Qishenbuqi capsules. Toxicol Res (Camb). 2023;12(2):201-215. Published 2023 Feb 14. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Divaricatol 関連分類
HY-N17727 関連分類
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