Eflornithine
Based on 23 publication(s) in Google Scholar
Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.87%
- CAS 番号: 70052-12-9
- 分子式: C6H12F2N2O2
- 分子量:182.17
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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MedChemExpress（MCE）の使用を引用している文献 Eflornithine
More- Nature. 2026 Jul;655(8121):240-250. [Abstract]
- Immunity. 2025 Aug 12;58(8):2019-2034.e11. [Abstract]
- Nat Commun. 2025 Dec 8. [Abstract]
- Nat Commun. 2024 Mar 19;15(1):2461. [Abstract]
- J Clin Invest. 2026 Jun 11.
- Adv Sci (Weinh). 2025 Nov 21:e12508. [Abstract]
- Sci Adv. 2023 May 19;9(20):eade0718. [Abstract]
- Phytomedicine. 2025 Jun:141:156660. [Abstract]
- Clin Cancer Res. 2025 Nov 20. [Abstract]
- JACC Basic Transl Sci. 2022 Aug 3;7(8):820-840. [Abstract]
- Cell Rep. 2025 Feb 28;44(3):115370. [Abstract]
- Cell Rep. 2025 Jan 28;44(1):115123. [Abstract]
- Food Biosci. 2023 Oct, 55, 102970.
- RSC Adv. 2019 Apr 9;9(20):11026-11037. [Abstract]
- Cancer Nanotechnol. 2023 May 9.
- Commun Biol. 2019 May 8:2:171. [Abstract]
- Front Oncol. 2021 Mar 11:11:636373. [Abstract]
- J Cardiovasc Transl Res. 2025 Jun;18(3):459-470. [Abstract]
- Biochem Biophys Res Commun. 2026 Feb 12:800:153251. [Abstract]
- Oncotargets Ther. 2020 Nov 17;13:11697-11709. [Abstract]
- The University of Texas at San Antonio. 2025.
- Preprints. 2025 May 22.
- bioRxiv. 2024 Jan 15.
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生物活性
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Trypanosoma |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>100 μM
Compound: Eflornithine
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay
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[PMID: 27720295] |
| HepG2 | CC50 |
>100 μM
Compound: Eflornithine
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32292551] |
| HepG2 | CC50 |
>100 μM
Compound: Eflornithine
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 32652409] |
| HepG2 | CC50 |
>100 μM
Compound: Eflornithine
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 32795774] |
| L6 | IC50 |
12 μg/mL
Compound: Eflornithine
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Cytotoxicity against in rat L6 cells assessed as reduction in cell viability after 70 hrs by alamar blue assay
Cytotoxicity against in rat L6 cells assessed as reduction in cell viability after 70 hrs by alamar blue assay
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[PMID: 21353728] |
| MRC5 | IC50 |
>100 μg/mL
Compound: eflornithine
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Cytotoxicity against human MRC5 cells after 7 days by MTT assay
Cytotoxicity against human MRC5 cells after 7 days by MTT assay
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[PMID: 19013823] |
| MRC5 | IC50 |
>100 μg/mL
Compound: Eflornithine
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Cytotoxicity against human MRC5 cells
Cytotoxicity against human MRC5 cells
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[PMID: 24388808] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 70052-12-9
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性状 Solid
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分子量 182.17
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分子式 C6H12F2N2O2
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Color White to light yellow
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SMILES
NC(CCCN)(C(F)F)C(O)=O
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別名
DFMO; MDL71782; RMI71782; α-difluoromethylornithine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (23)
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Journal Impact Factor
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Most Recent
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Nature
2026 Jul;655(8121):240-250. PMID: 42236947 -
Immunity
Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells. [Abstract]2025 Aug 12;58(8):2019-2034.e11. PMID: 40749666
Eflornithine purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Aug 12;58(8):2019-2034.e11. [Abstract]
Csnk2bTreg−/− and Csnk2bfl/fl mice were inoculated with B16.F10 cells and then orally administered Eflornithine hydrochloride hydrate (1% w/v) in combination with subcutaneous injection of AMXT 1501 around the tumor. We measured tumor growth and analyzed the phenotype of Treg cells in the tumor microenvironment (TME) using multicolor flow cytometry. The combination therapy had no effect on tumor growth in Csnk2bTreg−/− mice but significantly inhibited tumor growth in Csnk2bfl/fl mice.
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Nat Commun
2025 Dec 8. PMID: 41361241 -
Nat Commun
Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer. [Abstract]2024 Mar 19;15(1):2461. PMID: 38504107 -
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Adv Sci (Weinh)
Efferocytosis-Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer. [Abstract]2025 Nov 21:e12508. PMID: 41271556
Eflornithine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e12508. [Abstract]
Bar graphs showing the proportion of ALDH+ cells in OVCAR3, OVCAR8, and SKOV3 treated with THP-1-derived Mφ+ACs CM, THP-1-derived Mφ+ACs treated with 1 mM Eflornithine CM, respectively, for 48 h were presented.
Eflornithine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e12508. [Abstract]
Bar graph showing the relative mRNA expression of SOX2, ALDH1A1, and ALDH1A3 in OVCAR3 treated with THP-1 derived Mφ +ACs CM, THP-1 derived Mφ+ACs treated with 1 mM Eflornithine CM separately for 48 h.
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Sci Adv
Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation. [Abstract]2023 May 19;9(20):eade0718. PMID: 37205755
Eflornithine purchased from MedChemExpress. Usage Cited in: Sci Adv. 2023 May 19;9(20):eade0718. [Abstract]
Percentage of IFN-γ+ and mean fluorescence intensity (MFI) of Ki-67 in CD8+ T cells after anti-CD3 antibody stimulation versus anti-CD3 antibody plus rSema4A stimulation with or without Sardomozide Dihydrochloride (10 μM) and Eflornithine hydrochloride hydrate (500 μM).
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Phytomedicine
Oleic acid regulates CD4+ T cells differentiation by targeting ODC1-mediated STAT5A phosphorylation in Vogt-Koyanagi-Harada disease. [Abstract]2025 Jun:141:156660. PMID: 40203473 -
Clin Cancer Res
Spermidine Secreted by Apoptotic Cells Enhances Chemotherapy Resistance by Modulating β-Catenin Activity in Osteosarcoma. [Abstract]2025 Nov 20. PMID: 41263700 -
JACC Basic Transl Sci
Targeting Myocardial Mitochondria-STING-Polyamine Axis Prevents Cardiac Hypertrophy in Chronic Kidney Disease. [Abstract]2022 Aug 3;7(8):820-840. PMID: 36061341 -
Cell Rep
Intestinal microbiota affects the progression of colorectal cancer by participating in the host intestinal arginine catabolism. [Abstract]2025 Feb 28;44(3):115370. PMID: 40022728 -
Cell Rep
2025 Jan 28;44(1):115123. PMID: 39932195 -
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RSC Adv
Spermine modified polymeric micelles with pH-sensitive drug release for targeted and enhanced antitumor therapy. [Abstract]2019 Apr 9;9(20):11026-11037. PMID: 35520220 -
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Commun Biol
2019 May 8:2:171. PMID: 31098404
Eflornithine purchased from MedChemExpress. Usage Cited in: Commun Biol. 2019 May 8:2:171. [Abstract]
Eflornithine (DFMO) was administered as a 1% solution in drinking distilled H₂O to mice for 14 days. The mean DFMO consumption of mice was ∼1.5 g/kg/d. Immunostaining of IDO1 in the ileum after L-Orn administration in wt mice or after L-Orn inhibitor DFMO administration in human REG3Atg mice was performed.
Eflornithine purchased from MedChemExpress. Usage Cited in: Commun Biol. 2019 May 8:2:171. [Abstract]
Eflornithine (DFMO) was administered as a 1% solution in drinking distilled H₂O to mice for 14 days. The mean DFMO consumption of mice was ∼1.5 g/kg/d. HPLC/MASS of L-Kyn in the ileum epithelial cells after administration of L-Orn or L-Orn inhibitor DFMO.
Eflornithine purchased from MedChemExpress. Usage Cited in: Commun Biol. 2019 May 8:2:171. [Abstract]
Eflornithine (DFMO) was administered as a 1% solution in drinking distilled H₂O to mice for 14 days. The mean DFMO consumption of mice was ∼1.5 g/kg/d. Flow cytometry of RORγt (+) IL-22(+) cells in the ileum of mice after administering L-Orn or L-Orn inhibitor DFMO.
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Front Oncol
Dual Inhibition of Ornithine Decarboxylase and A1 Adenosine Receptor Efficiently Suppresses Breast Tumor Cells. [Abstract]2021 Mar 11:11:636373. PMID: 33777791 -
J Cardiovasc Transl Res
LACC1 Enhances Polyamine Immunometabolism in Inflammatory Macrophages to Inhibit Atherosclerosis Progression. [Abstract]2025 Jun;18(3):459-470. PMID: 40293654 -
Biochem Biophys Res Commun
Alpha-difluoromethylornithine suppresses angiogenesis via the FLI1-CLEC14A-VEGFC pathway in retinal endothelial cells. [Abstract]2026 Feb 12:800:153251. PMID: 41548484 -
Oncotargets Ther
Simultaneous Inhibition of Ornithine Decarboxylase 1 and Pyruvate Kinase M2 Exerts Synergistic Effects Against Hepatocellular Carcinoma Cells. [Abstract]2020 Nov 17;13:11697-11709. PMID: 33244237 -
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溶剤 & 溶解度
H2O : 83.33 mg/mL (457.43 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (∼50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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参考文献
[1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [Content Brief]
[2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [Content Brief]
[3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [Content Brief]
[4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.4894 mL | 27.4469 mL | 54.8938 mL | 137.2345 mL |
| 5 mM | 1.0979 mL | 5.4894 mL | 10.9788 mL | 27.4469 mL | |
| 10 mM | 0.5489 mL | 2.7447 mL | 5.4894 mL | 13.7234 mL | |
| 15 mM | 0.3660 mL | 1.8298 mL | 3.6596 mL | 9.1490 mL | |
| 20 mM | 0.2745 mL | 1.3723 mL | 2.7447 mL | 6.8617 mL | |
| 25 mM | 0.2196 mL | 1.0979 mL | 2.1958 mL | 5.4894 mL | |
| 30 mM | 0.1830 mL | 0.9149 mL | 1.8298 mL | 4.5745 mL | |
| 40 mM | 0.1372 mL | 0.6862 mL | 1.3723 mL | 3.4309 mL | |
| 50 mM | 0.1098 mL | 0.5489 mL | 1.0979 mL | 2.7447 mL | |
| 60 mM | 0.0915 mL | 0.4574 mL | 0.9149 mL | 2.2872 mL | |
| 80 mM | 0.0686 mL | 0.3431 mL | 0.6862 mL | 1.7154 mL | |
| 100 mM | 0.0549 mL | 0.2745 mL | 0.5489 mL | 1.3723 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Eflornithine 関連分類
HY-B0744 関連分類
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