EN171
Based on 1 Customer Validation
EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.14%
- CAS 番号: 2191110-79-7
- 分子式: C17H22N2O
- 分子量:270.37
-
保管条件:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Stem Cell Signaling Compound Library
HY-L017
-
Autophagy Compound Library
HY-L029
-
Anti-Aging Compound Library
HY-L034
-
Anti-Breast Cancer Compound Library
HY-L074
-
Anti-Liver Cancer Compound Library
HY-L101
-
Anti-Colorectal Cancer Compound Library
HY-L103
-
Nuclear Receptor Compound Library
HY-L126
-
Molecular Glue Compound Library
HY-L137
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Anti-Ovarian Cancer Compound Library
HY-L173
-
Multi-Target Compound Library
HY-L176
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Anti-Fibrosis Compound Library
HY-L185
-
High-Throughput Bioactive Compound Library
HY-L205
生物活性
化学情報
-
CAS 番号 2191110-79-7
-
性状 Oil
-
分子量 270.37
-
分子式 C17H22N2O
-
Color Colorless to off-white
-
SMILES
O=C(N1CCC2(CN(CC2)CC3=CC=CC=C3)C1)C=C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (92.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (268 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6986 mL | 18.4932 mL | 36.9864 mL | 92.4659 mL |
| 5 mM | 0.7397 mL | 3.6986 mL | 7.3973 mL | 18.4932 mL | |
| 10 mM | 0.3699 mL | 1.8493 mL | 3.6986 mL | 9.2466 mL | |
| 15 mM | 0.2466 mL | 1.2329 mL | 2.4658 mL | 6.1644 mL | |
| 20 mM | 0.1849 mL | 0.9247 mL | 1.8493 mL | 4.6233 mL | |
| 25 mM | 0.1479 mL | 0.7397 mL | 1.4795 mL | 3.6986 mL | |
| 30 mM | 0.1233 mL | 0.6164 mL | 1.2329 mL | 3.0822 mL | |
| 40 mM | 0.0925 mL | 0.4623 mL | 0.9247 mL | 2.3116 mL | |
| 50 mM | 0.0740 mL | 0.3699 mL | 0.7397 mL | 1.8493 mL | |
| 60 mM | 0.0616 mL | 0.3082 mL | 0.6164 mL | 1.5411 mL | |
| 80 mM | 0.0462 mL | 0.2312 mL | 0.4623 mL | 1.1558 mL |
EN171 関連分類
HY-W1005067 関連分類
Powered by Bioz