製品番号: HY-155747

FDW028

2 Cited Publications

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research.

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純度: 99.41%
CAS 番号: 2768426-49-7
分子式: C₂₂H₂₄N₆O
分子量:388.47

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

FDW028 構造式

CAS 番号: 2768426-49-7

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価格（税別）

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数量

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Akt アイソフォーム固有の製品をすべて表示 :

mTOR アイソフォーム固有の製品をすべて表示 :

体外実験

FDW028 (50 μM, 72 hours) promotes defucosylation and lysosomal degradation of B7-H3 and inhibits the AKT/MTOR pathway^[1].
FDW028 (50 μM, 72 hours) promotes B7-H3 and LAMP1 colocalization, facilitating lysosomal degradation of B7-H3^[1].
FDW028 (0.2–100 μM, 72 hours) significantly inhibits proliferation of SW480 and HCT-8 cells with IC50 values of 5.95 μM and 23.78 μM^[1].
FDW028 (50 μM, 72 hours) significantly inhibits migration in SW480 and HCT-8 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

SW480 cells, HCT-8 cells
Concentration:

0.2–100 μM
Incubation Time:

72 h
Result:

Promoted the colocalization of B7-H3 and LAMP1 in lysosomes.

Cell Proliferation Assay^[1]

Cell Line:

SW480 cells, HCT-8 cells
Concentration:

50 μM
Incubation Time:

72 h
Result:

Inhibited cell proliferation, with IC₅₀ values of 5.95 μM and 23.78 μM for SW480 and HCT-8, respectively.

Western Blot Analysis^[1]

Cell Line:

SW480 cells, HCT-8 cells
Concentration:

50 μM
Incubation Time:

72 h
Result:

Promoted defucosylation of B7-H3, facilitated lysosomal degradation, and inhibited the AKT/MTOR pathway.

Cell Migration Assay ^[1]

Cell Line:

SW480 cells, HCT-8 cells
Concentration:

50 μM
Incubation Time:

72 h
Result:

Inhibited the migration ability of SW480 and HCT-8 cells.

体内実験

FDW028 (10 or 20 mg/kg, i.v. every other day) exhibits significant anti-tumor activity in the SW480 xenograft mouse model^[1].
FDW028 (20 mg/kg, i.v. every other day) significantly prolongs survival in the Mc38 pulmonary metastasis model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Colorectal cancer cell line SW480 xenograft mouse model (C57BL/6 mice, 4-6 weeks)^[1]
Dosage:

10 mg/kg, 20 mg/kg
Administration:

Intravenous injection (i.v.), every other day, tumor size and body weight were measured every other day during the experiment
Result:

Inhibited tumor growth, comparable to 5-Fu (HY-90006), and did not cause significant weight loss.

Animal Model:

Mc38 colorectal cancer pulmonary metastasis mouse model (C57BL/6 mice, 4-6 weeks)^[1]
Dosage:

20 mg/kg
Administration:

Intravenous injection (i.v.), every other day, were measured every other day during the experiment
Result:

Significantly prolonged the survival of tumor-bearing mice.

化学情報

CAS 番号 2768426-49-7
性状 Solid
分子量 388.47
分子式 C₂₂H₂₄N₆O
Color White to off-white
SMILES

OC1=CC(CNCC2=CC=CC=C2)=NC3=NC(NCC4=CC=C(CC)C=C4)=NN31
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Int J Biol Macromol

Genome-wide CRISPR screen identifies ALG5, ALG6, NF2, and FUT8 as key host proteins involved in transmissible gastroenteritis virus infection. [Abstract]

2025 Dec;333(Pt 2):148770. PMID: 41205942
PLoS Pathog

FUT8-mediated core fucosylation of receptor APN drives entry of multiple alphacoronaviruses. [Abstract]

2026 May 18;22(5):e1014227. PMID: 42149951

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (257.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5742 mL

12.8710 mL

25.7420 mL

5 mM

0.5148 mL

2.5742 mL

5.1484 mL

10 mM

0.2574 mL

1.2871 mL

2.5742 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang M, et al. FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer. Cell Death Dis. 2023 Aug 3;14(8):495. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5742 mL	12.8710 mL	25.7420 mL	64.3550 mL
	5 mM	0.5148 mL	2.5742 mL	5.1484 mL	12.8710 mL
	10 mM	0.2574 mL	1.2871 mL	2.5742 mL	6.4355 mL
	15 mM	0.1716 mL	0.8581 mL	1.7161 mL	4.2903 mL
	20 mM	0.1287 mL	0.6436 mL	1.2871 mL	3.2178 mL
	25 mM	0.1030 mL	0.5148 mL	1.0297 mL	2.5742 mL
	30 mM	0.0858 mL	0.4290 mL	0.8581 mL	2.1452 mL
	40 mM	0.0644 mL	0.3218 mL	0.6436 mL	1.6089 mL
	50 mM	0.0515 mL	0.2574 mL	0.5148 mL	1.2871 mL
	60 mM	0.0429 mL	0.2145 mL	0.4290 mL	1.0726 mL
	80 mM	0.0322 mL	0.1609 mL	0.3218 mL	0.8044 mL
	100 mM	0.0257 mL	0.1287 mL	0.2574 mL	0.6436 mL

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FDW028

2 Cited Publications

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FDW028

Anti-Cancer Compound Library

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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

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Posttranslational Modification Library

Lactylation Compound Library

Kinase Inhibitor Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

MedChemExpress（MCE）の使用を引用している文献 FDW028

Akt アイソフォーム固有の製品をすべて表示

mTOR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (2)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

FDW028 関連分類

HY-155747 関連分類