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MIPOL1 - mirror-image polydactyly 1 Gene

Also Known as CCDC193

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 145282

About MIPOL1

Cytogenetic location: 14q13.3-q21.1 Genomic coordinates (GRCh38): 14:37,197,937-37,585,618 (from NCBI)

This gene has 30 transcripts (splice variants) and 177 orthologues. Broad expression in prostate (RPKM 1.7), testis (RPKM 0.6) and 20 other tissues.

Summary

This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor. A translocation that results in truncation of the protein encoded by this locus has been associated with mirror-image polydactyly, also known as Laurin-Sandrow Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2010]

MIPOL1 Products (14)

mRNA	Protein	Name
NM_001195296.2	NP_001182225.1	mirror-image polydactyly gene 1 protein isoform 1
NM_001195297.2	NP_001182226.1	mirror-image polydactyly gene 1 protein isoform 1
NM_001388067.1	NP_001374996.1	mirror-image polydactyly gene 1 protein isoform 1
NM_001388068.1	NP_001374997.1	mirror-image polydactyly gene 1 protein isoform 1
NM_001388069.1	NP_001374998.1	mirror-image polydactyly gene 1 protein isoform 2
NM_001388070.1	NP_001374999.1	mirror-image polydactyly gene 1 protein isoform 3
NM_001388071.1	NP_001375000.1	mirror-image polydactyly gene 1 protein isoform 3
NM_001388072.1	NP_001375001.1	mirror-image polydactyly gene 1 protein isoform 3
NM_001388073.1	NP_001375002.1	mirror-image polydactyly gene 1 protein isoform 4
NM_001388074.1	NP_001375003.1	mirror-image polydactyly gene 1 protein isoform 5
NM_001388075.1	NP_001375004.1	mirror-image polydactyly gene 1 protein isoform 5
NM_001388077.1	NP_001375006.1	mirror-image polydactyly gene 1 protein isoform 6
NM_001412440.1	NP_001399369.1	mirror-image polydactyly gene 1 protein isoform 7
NM_138731.7	NP_620059.1	mirror-image polydactyly gene 1 protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in nucleus	IDA IDA: Inferred from direct assay	19667180	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mirror-image polydactyly gene 1 protein

MIPOL1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MIPOL1	Q8TD10	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	RTP5	Homo sapiens	Q14D33	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	FBF1	Homo sapiens	Q8TES7-6	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	FBF1	Homo sapiens	Q8TES7-6	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	FBF1	Homo sapiens	Q8TES7-6	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	TTC12	Homo sapiens	Q9H892-2	Y2H Prey Pooling	26871637
Intra	MIPOL1	Q8TD10	TTC12	Homo sapiens	Q9H892-2	Validated Y2H	26871637
Intra	MIPOL1	Q8TD10	TTC12	Homo sapiens	Q9H892-2	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	TTC12	Homo sapiens	Q9H892-2	Y2H Array	26871637
Intra	MIPOL1	Q8TD10	SSX3	Homo sapiens	Q99909	Y2H Array	31515488
Intra	MIPOL1	Q8TD10	SSX3	Homo sapiens	Q99909	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	SSX3	Homo sapiens	Q99909	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	PPP1R13B	Homo sapiens	Q96KQ4	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	FAM124B	Homo sapiens	Q9H5Z6-2	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	SNAP91	Homo sapiens	O60641-3	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	SNAP91	Homo sapiens	O60641-3	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	PRPF31	Homo sapiens	Q8WWY3	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	SNTG2	Homo sapiens	Q9NY99-2	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	SNTG2	Homo sapiens	Q9NY99-2	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	SNTG2	Homo sapiens	Q9NY99-2	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	NEBL	Homo sapiens	O76041	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	KIAA1328	Homo sapiens	Q86T90	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	KIAA1328	Homo sapiens	Q86T90	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	ZGPAT	Homo sapiens	Q8N5A5	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	ATP5PO	Homo sapiens	P48047	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	ATP5PO	Homo sapiens	P48047	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	MCM7	Homo sapiens	P33993	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	MCM7	Homo sapiens	P33993	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	CCT3	Homo sapiens	P49368	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	BYSL	Homo sapiens	Q13895	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	TSEN15	Homo sapiens	Q8WW01	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	GADD45GIP1	Homo sapiens	Q8TAE8	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	EIF4E2	Homo sapiens	O60573	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	EIF4E2	Homo sapiens	O60573	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	SMARCE1	Homo sapiens	Q969G3	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	UBE2K	Homo sapiens	P61086	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	UBE2K	Homo sapiens	P61086	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	ANKRD23	Homo sapiens	Q86SG2	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	ANKRD23	Homo sapiens	Q86SG2	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	MYLIP	Homo sapiens	Q8WY64	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	MYLIP	Homo sapiens	Q8WY64	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	STMN3	Homo sapiens	Q9NZ72	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	STMN3	Homo sapiens	Q9NZ72	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	STMN3	Homo sapiens	Q9NZ72	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	LENG1	Homo sapiens	Q96BZ8	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	RBM41	Homo sapiens	Q96IZ5	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	RBM41	Homo sapiens	Q96IZ5	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	RBM41	Homo sapiens	Q96IZ5	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	TCHP	Homo sapiens	Q9BT92	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	TCHP	Homo sapiens	Q9BT92	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	MMTAG2	Homo sapiens	Q9BU76	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	RCOR3	Homo sapiens	Q9P2K3	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	CCDC120	Homo sapiens	Q96HB5	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	CCDC120	Homo sapiens	Q96HB5	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	BEX2	Homo sapiens	Q9BXY8	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	BEX2	Homo sapiens	Q9BXY8	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	CDK18	Homo sapiens	Q07002	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	CDK18	Homo sapiens	Q07002	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	CDK18	Homo sapiens	Q07002	Y2H Array	25416956
Intra	MIPOL1	Q8TD10	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	UTP25	Homo sapiens	Q68CQ4	Validated Y2H	25416956
Intra	MIPOL1	Q8TD10	UTP25	Homo sapiens	Q68CQ4	Y2H Array	29892012
Intra	MIPOL1	Q8TD10	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	EAF1	Homo sapiens	Q96JC9	Y2H Prey Pooling	25416956
Intra	MIPOL1	Q8TD10	DAXX	Homo sapiens	Q9UER7	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	MIPOL1	Q8TD10	TTC23	Homo sapiens	Q5W5X9-3	Y2H Array	32296183
Intra	MIPOL1	Q8TD10	TTC23	Homo sapiens	Q5W5X9-3	Y2H Prey Pooling	32296183
Intra	MIPOL1	Q8TD10	USH1C	Homo sapiens	Q9Y6N9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Polydactyly	Non-Syndromic Polydactyly Polydactyly, Postaxial Postaxial Polydactyly Supernumerary Digit Extra Digits Hyperdactyly Polydactylia Polydactylism Supernumerary Digits
Laurin-Sandrow Syndrome	Sandrow Syndrome Tetramelic Mirror-Image Polydactyly Mirror-Image Polydactyly Mirror Hands And Feet With Nasal Defects Tmip LSS Mip Mirror Hands And Feets-Nasal Defects Syndrome Fibula And Ulna, Duplication Of, With Absence Of Tibia And Radius Miccor Hands And Feet With Nasal Defects Mipduplication Of Fibuland Ulna With Absence Of Tibia And Radius Fibula Ulna Duplication Tibia Radius Absence Laurin Sandrow Syndrome Duplication Of Fibula And Ulna With Absence Of Tibia And Radius Segmental Laurin-Sandrow Syndrome Laurin-Sandrow Syndrome, Segmental
Bronchus Adenoma	Bronchial Adenoma Adenoma Of The Bronchus
Acute Laryngitis	Acute Laryngitis Nos Laryngeal Inflammation Laryngitis Nos Larynx Inflammation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS08462	MIPOL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	MIPOL1	VGNC	VGNC:106823
Canis familiaris	MIPOL1	VGNC	VGNC:43243
Felis catus	MIPOL1	VGNC	VGNC:80911
Rattus norvegicus	MIPOL1	RGD	RGD:6504372
Mus musculus	MIPOL1	MGD	MGI:1920740
Macaca mulatta	MIPOL1	VGNC	VGNC:74801
Others	MIPOL1	NCBI