CEACAM6 - CEA cell adhesion molecule 6 Gene

Also Known as NCA; CEAL; CD66c

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 4680

About CEACAM6

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,755,530-41,772,211 (from NCBI)

This gene has 2 transcripts (splice variants), 568 orthologues, 24 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 147.4), lung (RPKM 142.2) and 9 other tissues.

Summary

This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum Immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus Infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]

CEACAM6 Products (1)

mRNA Protein Name
NM_002483.7 NP_002474.4 carcinoembryonic antigen-related cell adhesion molecule 6 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables identical protein binding IDA
IDA: Inferred from direct assay
26483485 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
26483485 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: Inferred from mutant phenotype
2803308 GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules IMP
IMP: Inferred from mutant phenotype
2803308 GOA
involved in negative regulation of anoikis IMP
IMP: Inferred from mutant phenotype
10910050 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
16204051 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
25171863 GOA
involved in positive regulation of endothelial cell-matrix adhesion via fibronectin IMP
IMP: Inferred from mutant phenotype
16204051 GOA
involved in positive regulation of heterotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
16204051 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10436421 GOA
located in cell surface IDA
IDA: Inferred from direct assay
2317824 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
25645918 GOA
located in membrane IDA
IDA: Inferred from direct assay
2317824 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEACAM6 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (39 - 140)

Ig_3

Ig_3: Immunoglobulin domain (146 - 219)

Ig_2

Ig_2: Immunoglobulin domain (240 - 314)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

carcinoembryonic antigen-related cell adhesion molecule 6

  • Cluster of Differentiation 66c

CEACAM6 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CEACAM6 P40199 MSS51 Homo sapiens Q4VC12
Validated Y2H
32296183
Intra
CEACAM6 P40199 MSS51 Homo sapiens Q4VC12
Y2H Array
32296183
Intra
CEACAM6 P40199 MSS51 Homo sapiens Q4VC12
Y2H Prey Pooling
32296183
Intra
CEACAM6 P40199 POM121 Homo sapiens Q96HA1-2
Validated Y2H
32296183
Intra
CEACAM6 P40199 VEZF1 Homo sapiens Q14119
Validated Y2H
32296183
Intra
CEACAM6 P40199 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
CEACAM6 P40199 ASPG Homo sapiens Q86U10
Validated Y2H
32296183
Intra
CEACAM6 P40199 ASPG Homo sapiens Q86U10
Y2H Array
32296183
Intra
CEACAM6 P40199 ASPG Homo sapiens Q86U10
Y2H Prey Pooling
32296183
Intra
CEACAM6 P40199 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra
CEACAM6 P40199 QRICH1 Homo sapiens Q2TAL8
Validated Y2H
32296183
Intra
CEACAM6 P40199 EXOC3L1 Homo sapiens Q86VI1
Validated Y2H
32296183
Intra
CEACAM6 P40199 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
CEACAM6 P40199 RHOXF2 Homo sapiens Q9BQY4
Validated Y2H
32296183
Intra
CEACAM6 P40199 CIB1 Homo sapiens Q99828
Y2H Prey Pooling
32296183
Intra
CEACAM6 P40199 CIB1 Homo sapiens Q99828
Validated Y2H
32296183
Intra
CEACAM6 P40199 CIB1 Homo sapiens Q99828
Y2H Array
32296183
Intra
CEACAM6 P40199 CEACAM6 Homo sapiens P40199
Y2H Prey Pooling
32296183
Intra
CEACAM6 P40199 CEACAM6 Homo sapiens P40199
Protein Array
21982860
Intra
CEACAM6 P40199 CEACAM6 Homo sapiens P40199
Validated Y2H
32296183
Intra
CEACAM6 P40199 HPCAL4 Homo sapiens Q9UM19
Validated Y2H
32296183
Intra
CEACAM6 P40199 CEACAM6 Homo sapiens P40199
Y2H Array
32296183
Intra
CEACAM6 P40199 CEACAM6 Homo sapiens P40199
Solution Sedimentation
26483485
Intra
CEACAM6 P40199 CEACAM8 Homo sapiens P31997
X-Ray Diffraction
26483485
Intra
CEACAM6 P40199 HPCAL4 Homo sapiens Q9UM19
Y2H Array
32296183
Intra
CEACAM6 P40199 CEACAM6 Homo sapiens P40199
X-Ray Diffraction
26483485
Intra
CEACAM6 P40199 HPCAL4 Homo sapiens Q9UM19
Y2H Prey Pooling
32296183
Intra
CEACAM6 P40199 CARTPT Homo sapiens Q16568
Protein Array
21982860
Intra
CEACAM6 P40199 CARTPT Homo sapiens Q16568
SPR
21982860
Intra
CEACAM6 P40199 MYOZ1 Homo sapiens Q9NP98
Validated Y2H
32296183
Intra
CEACAM6 P40199 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Intra
CEACAM6 P40199 ZMYND19 Homo sapiens Q96E35
Y2H Prey Pooling
32296183
Intra
CEACAM6 P40199 ZMYND19 Homo sapiens Q96E35
Y2H Array
32296183
Intra
CEACAM6 P40199 PITX1 Homo sapiens P78337
Validated Y2H
32296183
Intra
CEACAM6 P40199 SHC3 Homo sapiens Q92529
Validated Y2H
32296183
Intra
CEACAM6 P40199 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
CEACAM6 P40199 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
CEACAM6 P40199 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CEACAM6 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P72131 CEACAM6 Protein, Human (His-SUMO) P40199 (K35-G320, V239G) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75671 CEACAM6 Protein, Human (Biotinylated, HEK293, His) P40199 (K35-G320) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78081 CEACAM6 Protein, Human (Biotinylated, HEK293, His-Avi) P40199 (K35-G320) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78397 CEACAM6 Protein, Human (HEK293, His-Avi) P40199 (K35-G320) ≥ 95%, as determined by Bis-Tris PAGE.

CEACAM6 抗体

製品番号 製品名 アプリケーション 反応性
HY-P83606 CEACAM6 Antibody (YA3351) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P84295 CEACAM6 Antibody (YA3992) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Rat
HY-P84295A CEACAM6 Antibody (YA3992)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Rat

関連疾患

Diseases Alias
Crohn'S Disease

  • Crohn Disease

  • Pediatric Crohn'S Disease

  • Regional Enteritis

  • Crohn'S Disease Of Large Bowel

  • Granulomatous Colitis

  • Enteritis, Granulomatous

  • Enteritis

  • Crohn'S Disease Of Colon

  • Colitis, Granulomatous

  • Crohn'S Enteritis

  • Enteritis, Regional

  • Ileitis

  • Adenoviral Enteritis

  • Acute Gastroenteropathy Due To Norwalk Agent

  • Viral Gastroenteritis Due To Norwalk Agent

  • Winter Vomiting

  • Epidemic Winter Vomiting Disease

  • Small Round Structured Virus Enteritis

  • Epidemic Vomiting Syndrome

  • Epidemic Vomiting

  • Epidemic Nausea

  • Epidemic Viral Gastroenteritis Due To Norwalk Virus

  • Noroviral Enteritis

  • Crohn Disease Nos

  • Crohns

  • Cd - [Crohn'S Disease]

  • Regional Enteritis Of Bowel

  • Crohn'S Regional Enteritis

  • Cobble-Stone Appearance Of Intestine

  • Intestinal Ulcer And Erosion Due To Crohn Disease

  • Granulomatous Enteritis
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Gastrointestinal Carcinoma

  • Gastrointestinal Neoplasms
Adenocarcinoma

  • Adenocarcinomas

  • Adenoacanthoma Of Unspecified Site

  • Adenocarcinoid Of Unspecified Site

  • Adenocarcinoid Tumour Of Unspecified Site

  • Adenocarcinoma And Carcinoid Combined Of Unspecified Site

  • Adenocarcinoma Nos
Pancreatic Adenocarcinoma

  • Adenocarcinoma Of The Pancreas

  • Adenocarcinoma Of Pancreas

  • Pancreas Adenocarcinoma

  • Malignant Exocrine Neoplasm

  • Primary Pancreatic Adenocarcinoma

  • Adenocarcinoma Of Islet Cell Of Pancreas

  • Islet Cell Adenocarcinoma Of Unspecified Site

  • Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Cholangiocarcinoma

  • Cholangiocarcinoma, Susceptibility To

  • Extrahepatic Cholangiocarcinoma

  • Intrahepatic Cholangiocarcinoma

  • Chlc

  • Chlc, Susceptibility To

  • Cc

  • Cholangiocarcinoma Of Biliary Tract

  • Cholangiocellular Carcinoma

  • Distal Cholangiocarcinoma

  • Perihilar Cholangiocarcinoma

  • Bile Duct Cancer

  • Cca

  • Adult Primary Cholangiocellular Carcinoma

  • Bile Duct Carcinoma
Ovarian Mucinous Adenocarcinoma

  • Mucinous Carcinoma Of Ovary
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

阻害性抗体 (1)
製品番号 製品名 製品効果
純度 Phase
HY-P99051 Tinurilimab Inhibitor 98.01% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-164899 2A3 99.92% Unkown
HY-RS02442 CEACAM6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24916 Ceacam6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P99691 Lemalesomab Inhibitor / Unkown
HY-P992344 DNP002 Inhibitor / Unkown
HY-P992350 EBC-129 Antibody / Unkown
HY-P990854 Anti-CEACAM1/3/5/6/8 Antibody (6G5j) Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus CEACAM6 RGD RGD:1642421
Others CEACAM6 NCBI