NRP1 - neuropilin 1 Gene

Also Known as NP1; NRP; BDCA4; CD304; VEGF165R

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 8829

About NRP1

Cytogenetic location: 10p11.22 Genomic coordinates (GRCh38): 10:33,177,493-33,334,667 (from NCBI)

This gene has 14 transcripts (splice variants), 260 orthologues and 35 paralogues. Broad expression in placenta (RPKM 53.3), fat (RPKM 49.6) and 24 other tissues.

Summary

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]

NRP1 Products (6)

mRNA	Protein	Name
NM_001024628.3	NP_001019799.2	neuropilin-1 isoform b precursor
NM_001024629.3	NP_001019800.2	neuropilin-1 isoform c precursor
NM_001244972.2	NP_001231901.2	neuropilin-1 isoform d precursor
NM_001244973.2	NP_001231902.2	neuropilin-1 isoform e precursor
NM_001330068.2	NP_001316997.2	neuropilin-1 isoform f precursor
NM_003873.7	NP_003864.5	neuropilin-1 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	26051942	GOA
enables growth factor binding	IPI IPI: Inferred from physical interaction	9529250	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16763549	GOA
enables vascular endothelial growth factor binding	IPI IPI: Inferred from physical interaction	24401374	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in VEGF-activated neuropilin signaling pathway	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	23639442	GOA
involved in cellular response to hepatocyte growth factor stimulus	IMP IMP: Inferred from mutant phenotype	21245381	GOA
involved in endothelial cell chemotaxis	IMP IMP: Inferred from mutant phenotype	21245381	GOA
involved in hepatocyte growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21245381	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in neuropilin signaling pathway	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21245381	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	26051942	GOA
involved in positive regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	24863063	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	26051942	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in regulation of Cdc42 protein signal transduction	IMP IMP: Inferred from mutant phenotype	26051942	GOA
acts upstream of substrate-dependent cell migration, cell extension	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in symbiont entry into host cell	IDA IDA: Inferred from direct assay	33000221	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21245381	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytosol	IDA IDA: Inferred from direct assay	21245381	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	24863063	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21245381	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRP1 Protein Structure

CUB

F5_F8_type_C

MAM

DUF3481

0
200
400
600
800
923 a.a.

Protein Preferred Names	Protein Names
neuropilin-1	transmembrane receptor

NRP1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	NRP1	O14786	VEGFA	Homo sapiens	P15692	ELISA	17222790
Intra	NRP1	O14786	VEGFA	Homo sapiens	P15692	Anti Tag CoIP	16763549
Intra	NRP1	O14786	ITGA5	Homo sapiens	P08648	Anti Bait CoIP	19175293
Cross	NRP1	O14786	S	SARS-CoV-2	P0DTC2	Anti Tag CoIP	33082294
Cross	NRP1	O14786	S	SARS-CoV-2	P0DTC2	ITC	33082294
Cross	NRP1	O14786	S	SARS-CoV-2	P0DTC2	X-Ray Diffraction	33082294
Intra	NRP1	O14786	FLNA	Homo sapiens	P21333	ITC	24021649

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NRP1 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P70147	Neuropilin-1 Protein, Human (HEK293, His)	AAH07533.1 (F22-K644)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72403	Neuropilin-1 Protein, Human (Biotinylated, HEK293, Avi-His)	AAH07533.1 (F22-K644)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73309	Neuropilin-1 Protein, Human (Biotinylated, HEK293, His-Avi, solution)	O14786-2 (F22-K644, V179A)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73310	Neuropilin-1 Protein, Human (V179A, HEK293, Fc)	O14786-2 (F22-K644, V179A)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P78751	Neuropilin-1 Protein, Human (HEK293, mFc)	AAH07533 (F22-K644)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78779	Neuropilin-1 Protein, Human (HEK293, Fc)	AAH07533 (F22-K644)	≥ 95%, as determined by reducing SDS-PAGE.

NRP1 抗体

製品番号	製品名	アプリケーション	反応性
HY-P82086	Neuropilin-1 Antibody (YA1831)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P82086A	Neuropilin-1 Antibody (YA1831)(PBS only)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P83810	Neuropilin-1 Antibody (YA3507)	WB, FC, ELISA	Human
HY-P83810A	Neuropilin-1 Antibody (YA3507)(PBS only)	WB, FC, ELISA	Human
HY-P86601	Neuropilin-1 Antibody (YA6293)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

関連疾患

Diseases	Alias
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1	Cadasil Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Casil Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Familial Vascular Leukoencephalopathy CADASIL1 Cadasil 1 Hereditary Multi-Infarct Dementia Cadasil Syndrome Dementia, Hereditary Multiinfarct Type Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1 Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1 Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy Dementia, Hereditary Multi-Infarct Type Hereditary Dementia, Multi-Infarct Type Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1 Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant Dementia Hereditary Multiinfarct Type Dementia Hereditary Multi-Infarct Type Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy
Neuroma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Brain Edema	Cerebral Edema Intracranial Swelling Wet Brain
Digeorge Syndrome	Chromosome 22q11.2 Deletion Syndrome DGS Hypoplasia Of Thymus And Parathyroids Third And Fourth Pharyngeal Pouch Syndrome 22q11.2 Deletion Syndrome Digeorge Sequence Digeorge'S Syndrome Pharyngeal Pouch Syndrome Di-George Syndrome Shprintzen Syndrome
Long Covid	Post-Acute Sequelae Of Sars-Cov-2 Infection Chronic Covid-19 Pasc Post-Covid Syndrome
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Angiomatous Meningioma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Charcot-Marie-Tooth Disease, Axonal, Type 2d	Charcot-Marie-Tooth Disease Type 2d CMT2D Charcot-Marie-Tooth Disease, Type 2d Autosomal Dominant Charcot-Marie-Tooth Disease Type 2d Charcot-Marie-Tooth Disease Neuronal Type 2d Charcot-Marie-Tooth Neuropathy Type 2d Charcot-Marie-Tooth Disease, Neuronal, Type 2d Charcot-Marie-Tooth Neuropathy, Type 2d Charcot-Marie-Tooth Disease 2d Charcot-Marie-Tooth Disease Axonal Type 2d
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Microvascular Complications Of Diabetes 5	Diabetic Retinopathy Microvascular Complications Of Diabetes, Susceptibility To, 5 MVCD5 Retinopathy, Diabetic Diabetic Nephropathy Retinopathy, Diabetic, Susceptibility To Retinal Abnormality - Diabetes-Related
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Exudative Vitreoretinopathy 1	Retinopathy Of Prematurity Retrolental Fibroplasia EVR1 Criswick-Schepens Syndrome Rop Exudative Vitreoretinopathy, Familial, Autosomal Dominant Fevr, Autosomal Dominant Premature Retinopathy Vitreoretinopathy, Exudative 1 Autosomal Dominant Familial Exudative Vitreoretinopathy Fevr Vitreoretinopathy, Exudative, Type 1 Retinopathy Of Prematurity Nos Rlf- [Retrolental Fibroplasia] Rop - [Retinopathy Of Prematurity] Terry Syndrome
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Phase
HY-P3448	Certepetide	Activator	99.80%	Phase 2

阻害性抗体 (2)

製品番号	製品名	製品効果	純度	Phase
HY-P99386	Vesencumab	Inhibitor	99.34%	Phase 1
HY-P991329	ASP-1948	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (25)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-10799	EG00229 trifluoroacetate	Antagonist	98.03%	Unkown
HY-112151A	EG01377 dihydrochloride	Inhibitor	98.98%	Unkown
HY-133034	NRP1 antagonist 1	Antagonist	99.71%	Unkown
HY-112151	EG01377	Inhibitor	99.90%	Unkown
HY-P1663A	ATWLPPR Peptide TFA	Inhibitor	99.20%	Unkown
HY-P10787	tLyP-1 peptide	Inhibitor	98.05%	Unkown
HY-RS09579	NRP1 Human Pre-designed siRNA Set A		/	Unkown
HY-147762	NRP1 antagonist 2	Antagonist	99.05%	Unkown
HY-P10097	Flt2-11	Inhibitor	99.71%	Unkown
HY-182700	NRPa-308	Inhibitor	98.96%	Unkown
HY-P11286	A7RC		99.87%	Unkown
HY-P11647A	RPARPAR acetate	Ligand	99.47%	Unkown
HY-RS16529	Nrp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-163062	Tubulin/NRP1-IN-1		/	Unkown
HY-179350	EG01449 Free acid	Inhibitor	/	Unkown
HY-179350A	EG01449	Inhibitor	/	Unkown
HY-18333	EG00229	Inhibitor	/	Unkown
HY-NP223	PLGF-2 Protein, human		/	Unkown
HY-P10788	CK3 peptide	Inhibitor	/	Unkown
HY-P11647	RPARPAR	Ligand	/	Unkown
HY-RS09204	NELL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-128446	CAY10781	Inhibitor	98.04%	Unkown
HY-P3448S	Certepetide-13C6,15N2	Activator	/	Unkown
HY-P3448S1	Certepetide-13C2,15N	Activator	/	Unkown
HY-RS22960	Nrp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	NRP1	VGNC	VGNC:32266
Macaca mulatta	NRP1	VGNC	VGNC:75532
Felis catus	NRP1	VGNC	VGNC:68569
Mus musculus	NRP1	MGD	MGI:106206
Rattus norvegicus	NRP1	RGD	RGD:621588
Canis familiaris	NRP1	VGNC	VGNC:43974
Others	NRP1	NCBI