Immuno modulator-1
Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM.
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- CAS 番号: 2757469-20-6
- 分子式: C32H31FN6O4
- 分子量:582.62
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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IL-2 |
Immuno modulator-1 (compound 22) inhibits the proliferation of NCI-H929 human myeloma cell, with an IC50 of 0.6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[1]
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Dosage:1 mg/kg (IV), 5 mg/kg (PO)
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Administration:IV (2 mL/kg), PO (10 mL/kg); once (Pharmacokinetic Analysis)
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Result:Pharmacokinetic Parameters of Immuno modulator-1 in male Sprague-Dawley rats[1].
IV (1 mg/kg) PO (5 mg/kg) Cmax (ng/mL) 1437 AUC0-24 (ng/mL∗h) 13029 CL (mL/min/kg) 2.2 Vss (L/kg) 0.36 F (%) 30%
化学情報
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CAS 番号 2757469-20-6
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分子量 582.62
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分子式 C32H31FN6O4
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SMILES
C[C@@H](N1CCN(C2=C(C=C(C=N2)C#N)F)CC1)C(C=C3)=CC=C3COC4=C5C(C(N([C@@H]6C(NC(CC6)=O)=O)C5)=O)=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Immuno modulator-1 関連分類
HY-153952 関連分類
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