Ipsapirone
Based on 1 Customer Validation
Ipsapirone (TVX Q 7821) is an anxiolytic compound and a 5-HT1A receptor partial agonist. Ipsapirone (TVX Q 7821) also exhibits 5-HT1A receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT2 and the α1-adrenergic function.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.45%
- CAS 番号: 95847-70-4
- 分子式: C19H23N5O3S
- 分子量:401.49
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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5-HT1A Receptor |
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
8.2 nM
Compound: Ipsapirone
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Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
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[PMID: 15341483] |
Ipsapirone (2.5-80 mg/kg), given alone to rats induces a slight flattening of body posture (~ 1 point at the highest dose) and a mild hind limb abduction observed at doses 2.5-80 mg/kg. Ipsapirone given alone at low doses (2.5-10 mg/kg i.p.) does not significantly change the body temperature in rats and mice, but decreased it in both those species at high doses (35 mg/kg i.p.) by ca. 2-2.5°C[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Albino-Swiss mice (18-24 g) and male Wistar rats (160-200 g)[1].
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Dosage:5 and 10 mg/kg.
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Administration:IP 30 min before 8-OH-DPAT and 5-MeODMT injections.
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Result:Behavioural responses (flat body posture, forepaw treading) to 8-OH-DPAT (5 mg/kg s.c.) in rats were antagonized by Ipsapirone (5 and 10 mg/kg i.p.).
化学情報
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CAS 番号 95847-70-4
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性状 Solid
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分子量 401.49
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分子式 C19H23N5O3S
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Color White to off-white
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SMILES
O=C(C1=C2C=CC=C1)N(CCCCN3CCN(C4=NC=CC=N4)CC3)S2(=O)=O
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別名
TVX Q 7821 free base
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (62.27 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. J Maj, et al. Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions. J Neural Transm. 1987;70(1-2):1-17. [Content Brief]
[2]. Stephen M. Stahl, et al. Effectiveness of ipsapirone, a 5-HT-1A partial agonist, in major depressive disorder: support for the role of 5-HT-1A receptors in the mechanism of action of serotonergic antidepressants. Int J Neuropsychopharmacol. 1998 Jul;1(1):11-18. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4907 mL | 12.4536 mL | 24.9072 mL | 62.2681 mL |
| 5 mM | 0.4981 mL | 2.4907 mL | 4.9814 mL | 12.4536 mL | |
| 10 mM | 0.2491 mL | 1.2454 mL | 2.4907 mL | 6.2268 mL | |
| 15 mM | 0.1660 mL | 0.8302 mL | 1.6605 mL | 4.1512 mL | |
| 20 mM | 0.1245 mL | 0.6227 mL | 1.2454 mL | 3.1134 mL | |
| 25 mM | 0.0996 mL | 0.4981 mL | 0.9963 mL | 2.4907 mL | |
| 30 mM | 0.0830 mL | 0.4151 mL | 0.8302 mL | 2.0756 mL | |
| 40 mM | 0.0623 mL | 0.3113 mL | 0.6227 mL | 1.5567 mL | |
| 50 mM | 0.0498 mL | 0.2491 mL | 0.4981 mL | 1.2454 mL | |
| 60 mM | 0.0415 mL | 0.2076 mL | 0.4151 mL | 1.0378 mL |
Ipsapirone 関連分類
HY-19686 関連分類
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