Isethionic acid (80% in water)
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Isethionic acid is a calcium binder and anionic detergent that enhances mitochondrial calcium binding capacity by competitively binding to calcium binding sites on the outer mitochondrial membrane. Isethionic acid can inhibit calcium-activated mitochondrial respiration. Isethionic acid inhibits barnacle (Balanus amphitrite) larvae with LC50s of 23 μg/mL (24 h) and 17 μg/mL (48 h), respectively. Isethionic acid can inhibit the attachment of barnacle larvae (complete inhibition at 10 μg/mL) and regulate mitochondrial calcium transport, and can enhance ATP-dependent calcium uptake at high calcium concentrations. Isethionic acid can be used to study the mechanism of mitochondrial calcium metabolism.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 80.00%
- CAS 番号: 107-36-8
- 分子式: C2H6O4S
- 分子量:126.13
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保管条件:
Solution, -20°C, 2 years
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Human Endogenous Metabolite |
Isethionic acid (3×10-5-6×10-4; 30 min) inhibits 4 mM CaCl2-activated respiration in rat liver mitochondrial respiration assay, with a maximum inhibition rate of 85% (6×10-4 M), and does not affect phosphate production[2].
Isethionic acid (3×10-4 M; 1 min) increases calcium uptake under 10 mM Ca2+ conditions in an ATP-dependent calcium uptake assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 107-36-8
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性状 Liquid
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分子量 126.13
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分子式 C2H6O4S
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Color Colorless to light yellow
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SMILES
O=S(CCO)(O)=O
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別名
2-Hydroxyethanesulfonic acid
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Solution, -20°C, 2 years
純度とドキュメンテーション
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データシート (269 KB)
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SDS (615 KB)
- English - EN (615 KB)
- Français - FR (615 KB)
- Deutsch - DE (615 KB)
- Norwegian - NO (615 KB)
- Español - ES (615 KB)
- Swedish - SV (615 KB)
- Italian - IT (615 KB)
- Korean - KR (615 KB)
- Portuguese - PT (615 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Hellio C, et al. Isethionic acid and floridoside isolated from the red alga, Grateloupia turuturu, inhibit settlement of Balanus amphitrite cyprid larvae. Biofouling. 2004 Jun;20(3):139-45. [Content Brief]
[2]. Dolara P, et al. Effect of 2-aminoethanesulphinic acid (taurine) and 2-hydroxyethane sulphonic acid (isethionic acid) on calcium transport by rat liver mitochondria. Biochem Pharmacol. 1973 Sep 1;22(17):2085-94. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Isethionic acid (80% in water) 関連分類
HY-Y0095 関連分類
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