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製品番号: HY-113581

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Levemopamil

Levemopamil is a calcium channel blocker and 5-HT₂ receptor antagonist. Levemopamil exerts renoprotective effects against ischemic acute kidney injury. Levemopamil is applicable to research related to ischemic acute renal failure.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 101238-51-1
分子式: C₂₃H₃₀N₂
分子量:334.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Levemopamil 構造式

CAS 番号: 101238-51-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Calcium Channel アイソフォーム固有の製品をすべて表示 :

5-HT Receptor アイソフォーム固有の製品をすべて表示 :

体内実験

Levemopamil (6 mg/kg/h; intravenous administration; continuous infusion; 7 h) transiently converts oliguria to non-oliguria, maintains low-level glomerular filtration function, and protects cortical mitochondrial ATP synthesis in a rat model of oliguric ischemic acute kidney injury^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (female, adult, 191-239 g, left unilateral renal artery occlusion for 1 hour followed by 6 hours of reperfusion/reflow)^[1]
Dosage:

6 mg/kg/h
Administration:

i.v.; continuous infusion; from 1 hour before ischaemia until 6 hours after reflow
Result:

Significantly increased urine flow and maintained measurable endogenous creatinine clearance in the ischaemic left kidney at 2 and 6 h of reperfusion.
Largely preserved mitochondrial ATP synthesis and normal ADP/O ratio.
Slightly attenuated the rise in cortical mitochondrial calcium content.

化学情報

CAS 番号 101238-51-1
分子量 334.50
分子式 C₂₃H₃₀N₂
SMILES

CN(CCC1=CC=CC=C1)CCC[C@@](C#N)(C2=CC=CC=C2)C(C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Animals and Diseases

Nephrotoxicity Study
This protocol assesses nephrotoxicity by combining functional kidney injury readouts, urinary/tissue injury biomarkers, and renal histopathology. Serum creatinine and BUN reflect impaired kidney function, while KIM-1, NGAL, clusterin, osteopontin, IL-18, cystatin C, nephrin, Oat5, urinary protein, glucose, and alkaline phosphatase have been used to detect tubular injury in cisplatin-, gentamicin-, and acetaminophen-induced nephrotoxicity models.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kramer HJ, et al. Calcium entry and 5-HT2 receptor blockade in oliguric ischaemic acute renal failure: effects of levemopamil in conscious rats. Br J Pharmacol. 1996;117(6):1348-1354. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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生物活性
- 製品説明
- 体内実験
化学情報
プロトコル
純度とドキュメンテーション
参考文献

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製品番号:
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Levemopamil

Calcium Channel アイソフォーム固有の製品をすべて表示

5-HT Receptor アイソフォーム固有の製品をすべて表示