Mahanine
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Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.0%
- CAS 番号: 28360-49-8
- 分子式: C23H25NO2
- 分子量:347.45
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Leishmania |
Mahanine (0-50 μM; 24 or 48 hours) induces a dose-dependent decrease in cell viability of AG83 promastigotes after 24 hr and 48 hr; the IC50 values were 16.7±1.7 μM and 11.5±0.8 μM respectively. In a drug resistant GE1 strain, Mahanine treatment exhibits dose-dependent cell death in 24 and 48 hr treatment with IC50 values 40.3±2.2 μM and 29.1±1.3 μM respectively[1].Mahanine (5.0 and 10 μM; 24 hours) exhibits increased accumulation of cells at G2/M phase being 39.0±1.90% and 41.0±2.10% respectively compared to untreated promastigotes (35.3 ± 2.60%) in AG83 promastigote [1].Mahanine (25 μM; 24 hours) exhibitssignificantly increased intracellular ROS level within 20 min (MFI being 889 ± 26) which reached to 1288 ± 56 after one hour compared to the basal level (604 ± 34) in untreated promastigote. H2DCFDA positivity was measured by FACS[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice with virulent AG83 promastigotes[1]
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Dosage:20 mg/kg-40 mg/kg
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Administration:oral gavage; 20 mg/kg/40 mg/kg; b.w/day; 5 days
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Result:Had the potential to clear parasite burden in vivo.Exhibited almost complete reduction of parasite burden, upregulation of NO/iNOS/ROS/IL-12 and T cell proliferation in vivo.
化学情報
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CAS 番号 28360-49-8
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性状 Solid
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分子量 347.45
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分子式 C23H25NO2
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Color Light yellow to brown
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SMILES
OC1=CC2=C(C3=C(N2)C4=C(C(C)=C3)O[C@@](CC/C=C(C)/C)(C)C=C4)C=C1
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kaushik Bhattacharya, et al. Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. Biochem Pharmacol. 2010 Feb 1;79(3):361-72. [Content Brief]
[2]. Saptarshi Roy, et al. Mahanine exerts in vitro and in vivo antileishmanial activity by modulation of redox homeostasis. Sci Rep [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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