MEDI-5083
MEDI-5083 is an Fc fusion protein that targets CD40 and is a CD40 agonist. MEDI-5083 stimulates CD40 signaling via NF-κB activation. MEDI-5083 upregulates MHCII, CD80, and CD86 expression, induces pro-inflammatory cytokine secretion, and enhances IFN-γ secretion by memory CD8+ T cells. MEDI-5083 can be used for the research of melanoma, colon carcinoma, and advanced solid tumors[1][2].
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
CD40L fused to a Fc fragment
Human
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CD40 |
NF-κB |
MHC II |
MEDI-5083 specifically binds human CD40, triggers its internalization, and robustly stimulates NF-κB-mediated CD40 signaling in human Ramos and THP-1 cells[1].
MEDI-5083 potently upregulates MHCII, CD80, and CD86 expression and induces pro-inflammatory cytokine secretion in primary human B cells and myeloid cells[1].
MEDI-5083 enhances IFN-γ secretion by human memory CD8+ T cells in an antigen-recall assay[1].
MEDI-5083 activates the CD40 pathway in human antigen-presenting cells and human monocyte-derived dendritic cells, upregulating co-stimulation molecules and inducing pro-inflammatory cytokine secretion[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
化学情報
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MEDI-5083 関連分類
HY-P992408 関連分類
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