MS21
Based on 1 Customer Validation
MS21 is an effective AKT PROTAC degrader. MS21 can inhibit mutations in the PI3K/PTEN pathway, suppress the proliferation and induce cell cycle arrest of tumor cells. MS21 has anti-tumor activity. (Pink: AKT ligand-2 (HY-48682); Black: Linker (HY-W014125); Blue: (S,R,S)-AHPC (HY-125845)).
(Pink: Akt ligand (HY-48682); Blue: VHL ligand (HY-125845); Black: linker (HY-W014125)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.64%
- CAS 番号: 2376137-05-0
- 分子式: C58H79ClN12O6S
- 分子量:1107.84
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
MS21 (1-1000 nM; 24 h) inhibits AKT protein levels and downstream signaling in PC-3 (DC50: 8.8 nM) and BT474 cells[1].
MS21 (0.1-10 μM; 2-17 days) can inhibit the proliferation of various cell lines such as PC-3 and MDA-MB-468 and induce cell cycle arrest[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3 cells
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Concentration:1, 3, 10, 30, 100, 300 and 1000 nM
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Incubation Time:24 h
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Result:Inhibited the level of T-Akt in a concentration‐dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:PC-3/MDA-MB-468 treated Nude mice[1]
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Dosage:75 mg/kg
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Administration:Intraperitoneal injection (i.p.); 21 days
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Result:Led to more than 90% tumor growth inhibition relative to vehicle treatment in PC-3 xenograft model and more than 80% in MDA-MB-468 xenograft model.
Reduced T-AKT protein levels in tumors, inhibited downstream signaling such as p-S6, decreased Ki67 staining, and somewhat upregulated the apoptosis marker cleaved caspase-3.
Did not cause significant weight loss or other overt toxicities, and the increase in blood glucose levels after treatment was less than that of AZD5363 (HY-15431).
化学情報
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CAS 番号 2376137-05-0
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性状 Solid
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分子量 1107.84
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分子式 C58H79ClN12O6S
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Color White to off-white
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SMILES
NC1(CCN(C2=NC=NC3=C2C=CN3)CC1)C(N[C@@H](CCN4CCN(C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)CC4)C8=CC=C(Cl)C=C8)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
Methanol : 95 mg/mL (85.75 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Methanol | 1 mM | 0.9027 mL | 4.5133 mL | 9.0266 mL | 22.5664 mL |
| 5 mM | 0.1805 mL | 0.9027 mL | 1.8053 mL | 4.5133 mL | |
| 10 mM | 0.0903 mL | 0.4513 mL | 0.9027 mL | 2.2566 mL | |
| 15 mM | 0.0602 mL | 0.3009 mL | 0.6018 mL | 1.5044 mL | |
| 20 mM | 0.0451 mL | 0.2257 mL | 0.4513 mL | 1.1283 mL | |
| 25 mM | 0.0361 mL | 0.1805 mL | 0.3611 mL | 0.9027 mL | |
| 30 mM | 0.0301 mL | 0.1504 mL | 0.3009 mL | 0.7522 mL | |
| 40 mM | 0.0226 mL | 0.1128 mL | 0.2257 mL | 0.5642 mL | |
| 50 mM | 0.0181 mL | 0.0903 mL | 0.1805 mL | 0.4513 mL | |
| 60 mM | 0.0150 mL | 0.0752 mL | 0.1504 mL | 0.3761 mL | |
| 80 mM | 0.0113 mL | 0.0564 mL | 0.1128 mL | 0.2821 mL |
MS21 関連分類
HY-141807 関連分類
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