MS31
Based on 3 publication(s) in Google Scholar
MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2366264-12-0
- 分子式: C20H27N3O2
- 分子量:341.45
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 MS31
More
生物活性
IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP)[1]
Kd: 91 nM (SPIN1)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| U2OS | IC50 |
3.2 μM
Compound: 3; MS31
|
Inhibition of C-terminal Halo Tag-histone H3.3/N-terminal Nano Luciferase-fused full length SPIN1 (unknown origin) transfected in human U2OS cells assessed as reduction in SPIN1 and histone H3 interaction incubated for 24 hrs by NanoBRET assay
Inhibition of C-terminal Halo Tag-histone H3.3/N-terminal Nano Luciferase-fused full length SPIN1 (unknown origin) transfected in human U2OS cells assessed as reduction in SPIN1 and histone H3 interaction incubated for 24 hrs by NanoBRET assay
|
[PMID: 31260300] |
MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays high binding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engages SPIN1 in cells, and is not toxic to nontumorigenic cells. MS31 selectively binds tudor domain II of SPIN1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 2366264-12-0
-
分子量 341.45
-
分子式 C20H27N3O2
-
SMILES
NCC1=CC(CN)=C(OC)C(OCCCN2CC(C=CC=C3)=C3C2)=C1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Nat Cell Biol
Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks. [Abstract]2025 Jun;27(6):992-1005. PMID: 40447771 -
Adv Sci (Weinh)
Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins. [Abstract]2025 Nov 29:e17751. PMID: 41316889 -
Nat Struct Mol Biol
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1. [Abstract]2025 Apr 17. PMID: 40247146
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MS31 関連分類
HY-125837 関連分類
Powered by Bioz