NEPP11
NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion.
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- CAS 番号: 313051-12-6
- 分子式: C26H36O3
- 分子量:396.57
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MEK アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
ERK1 |
ERK2 |
MEK1 |
MEK2 |
C-Raf |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-12 | Inhibition |
50 %
Compound: 1, NEPP11
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Inhibition of manganese ion-induced apoptosis in PC12 cells assessesed as suppression of DNA fragmentation at 10 uM
Inhibition of manganese ion-induced apoptosis in PC12 cells assessesed as suppression of DNA fragmentation at 10 uM
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[PMID: 17706424] |
化学情報
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CAS 番号 313051-12-6
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分子量 396.57
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分子式 C26H36O3
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SMILES
C(CCCCCC1=CC=C(C)C=C1)[C@H]2/C(=C\CCCCCC(OC)=O)/C(=O)C=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NEPP11 関連分類
HY-180327 関連分類
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