PPM-3
Based on 1 Customer Validation
PPM-3 is a potent and selective PROTAC ERK5 degrader, with an IC50 of 62.4 nM. PPM-3 did not influence tumor cell growth directly. PPM-3 influences tumor development by affecting the differentiation of macrophages.
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- CAS 番号: 3032388-42-1
- 分子式: C54H69N11O6S
- 分子量:1000.26
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
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ERK5 62.4 ± 18. nM (IC50) |
PPM-3 (200 nM, 0-72 h, A375 cells)-mediated degradation of ERK5 begins within 2-4 h and that degradation peaks at 12 h and lasts at least 72 h[1].
PPM-3 (0-1 μM, 12 h) shows ERK5 degradation activity in H1975, HepG2, MDA-MB-231, PC-3, HCT116, and A375 cancer cell lines, with DC50 values of 11.5+2.5, 13.7+8.2, 22.7+13.3, 23.5+10.3, 5.6+1.9, and 41.4+22.3 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3032388-42-1
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性状 Solid
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分子量 1000.26
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分子式 C54H69N11O6S
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Color White to off-white
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SMILES
O=C(C1=CC=CC=C1N(C)C2=NC(NC3=CC=C(C=C3OC)N4CCN(CC4)CCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(N[C@H](C6=CC=C(C=C6)C7=C(N=CS7)C)C)=O)O)=O)=O)=NC=C28)N8C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PPM-3 関連分類
HY-149616 関連分類
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