RS 39604
Based on 1 publication(s) in Google Scholar
RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 167710-87-4
- 分子式: C26H37Cl2N3O6S
- 分子量:590.56
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 RS 39604
More5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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5-HT1A Receptor |
5-HT2C Receptor |
5-HT4 Receptor 9.1 (pKi) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>13.05 μM
Compound: GNF-Pf-5475
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NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
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[PMID: 18579783] |
化学情報
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CAS 番号 167710-87-4
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性状 Solid
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分子量 590.56
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分子式 C26H37Cl2N3O6S
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Color White to off-white
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SMILES
CS(=O)(NCCN1CCC(CCC(C2=CC(Cl)=C(N)C=C2OCC3=CC(OC)=CC(OC)=C3)=O)CC1)=O.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Neuron
2025 Apr 10:S0896-6273(25)00220-X. PMID: 40233747
溶剤 & 溶解度
DMSO : 50 mg/mL (84.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6933 mL | 8.4665 mL | 16.9331 mL | 42.3327 mL |
| 5 mM | 0.3387 mL | 1.6933 mL | 3.3866 mL | 8.4665 mL | |
| 10 mM | 0.1693 mL | 0.8467 mL | 1.6933 mL | 4.2333 mL | |
| 15 mM | 0.1129 mL | 0.5644 mL | 1.1289 mL | 2.8222 mL | |
| 20 mM | 0.0847 mL | 0.4233 mL | 0.8467 mL | 2.1166 mL | |
| 25 mM | 0.0677 mL | 0.3387 mL | 0.6773 mL | 1.6933 mL | |
| 30 mM | 0.0564 mL | 0.2822 mL | 0.5644 mL | 1.4111 mL | |
| 40 mM | 0.0423 mL | 0.2117 mL | 0.4233 mL | 1.0583 mL | |
| 50 mM | 0.0339 mL | 0.1693 mL | 0.3387 mL | 0.8467 mL | |
| 60 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7055 mL | |
| 80 mM | 0.0212 mL | 0.1058 mL | 0.2117 mL | 0.5292 mL |
RS 39604 関連分類
HY-101343 関連分類
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