(S)-4C3HPG
(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of mGluR1a and an agonist of mGluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice.
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- CAS 番号: 85148-82-9
- 分子式: C9H9NO5
- 分子量:211.17
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>100 μM
Compound: 21
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Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
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[PMID: 15801843] |
| HEK293 | IC50 |
40 μM
Compound: 34
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Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells
Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells
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[PMID: 10229625] |
体外実験
The mGluR1a/mGluR2 receptor refers to a subtype of metabolite glutamate receptor, belonging to the G protein-coupled receptor superfamily. mGluR1a is mainly distributed on the postsynaptic membrane of the central nervous system, regulating synaptic plasticity, while mGluR2 acts as a presynaptic autoreceptor, negatively inhibiting glutamate release. Both are important targets for drug development in neurological diseases.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 85148-82-9
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分子量 211.17
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分子式 C9H9NO5
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SMILES
OC1=C(C(O)=O)C=CC([C@H](N)C(O)=O)=C1
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別名
(S)-4-Carboxy-3-hydroxyphenylglycine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. C Thomsen, et al. (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994 Jun;62(6):2492-5. [Content Brief]
[2]. Thomsen C, et al. (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994 Jun;62(6):2492-5. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(S)-4C3HPG 関連分類
HY-100840 関連分類
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