Simufilam
Based on 1 publication(s) in Google Scholar
Simufilam (PTI-125) is an orally active FLNA modulator. Simufilam restores NMDAR signaling and Arc expression. Simufilam inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam can be used for research of Alzheimer's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.78%
- CAS 番号: 1224591-33-6
- 分子式: C15H21N3O
- 分子量:259.35
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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溶剤 & 溶解度
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MedChemExpress（MCE）の使用を引用している文献 Simufilam
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生物活性
Simufilam (1 nM; 1 h) reduces FLNA-α7nAChR/TLR4 associations, dissociates Aβ42-α7nAChR complexes, restores α7nAChR/NMDAR/IR function, and decreases tau phosphorylation in postmortem human AD brain slices[2].
Simufilam (1 pM-1 nM; 1 h) dose-dependently reduces FLNA-α7nAChR/TLR4 associations, Aβ42-α7nAChR complexes, tau phosphorylation, and tau nitration, while restoring NMDAR signaling and Arc expression in postmortem human AD hippocampal slices[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Simufilam (30 mg/kg/d; p.o.; 2 months) reduces FLNA-α7nAChR/TLR4 associations, tau phosphorylation, Aβ42 deposits, and NFTs, improves NMDAR/IR function and synaptic plasticity, and enhances spatial/working memory and nesting behavior in 3xTg AD mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1224591-33-6
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性状 Solid-Liquid Mixture
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分子量 259.35
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分子式 C15H21N3O
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Color White to off-white
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SMILES
O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1
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別名
PTI-125
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Neurooncol
Single-cell RNA-seq reveals diverse molecular signatures associated with Methotrexate resistance in primary central nervous system lymphoma cells. [Abstract]2025 Mar;172(1):163-173. PMID: 39636551
溶剤 & 溶解度
DMSO : 50 mg/mL (192.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (393 KB)
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参考文献
[1]. Wang HY, et al. Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer's disease patient lymphocytes. Front Aging. 2023 Jun 29;4:1175601. [Content Brief]
[2]. Wang HY, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012 Jul 18;32(29):9773-84. [Content Brief]
[3]. Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017 Jul;55:99-114. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8558 mL | 19.2790 mL | 38.5579 mL | 96.3948 mL |
| 5 mM | 0.7712 mL | 3.8558 mL | 7.7116 mL | 19.2790 mL | |
| 10 mM | 0.3856 mL | 1.9279 mL | 3.8558 mL | 9.6395 mL | |
| 15 mM | 0.2571 mL | 1.2853 mL | 2.5705 mL | 6.4263 mL | |
| 20 mM | 0.1928 mL | 0.9639 mL | 1.9279 mL | 4.8197 mL | |
| 25 mM | 0.1542 mL | 0.7712 mL | 1.5423 mL | 3.8558 mL | |
| 30 mM | 0.1285 mL | 0.6426 mL | 1.2853 mL | 3.2132 mL | |
| 40 mM | 0.0964 mL | 0.4820 mL | 0.9639 mL | 2.4099 mL | |
| 50 mM | 0.0771 mL | 0.3856 mL | 0.7712 mL | 1.9279 mL | |
| 60 mM | 0.0643 mL | 0.3213 mL | 0.6426 mL | 1.6066 mL | |
| 80 mM | 0.0482 mL | 0.2410 mL | 0.4820 mL | 1.2049 mL | |
| 100 mM | 0.0386 mL | 0.1928 mL | 0.3856 mL | 0.9639 mL |
Simufilam 関連分類
HY-139142 関連分類
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