SJF-8240
Based on 1 Customer Validation
SJF-8240 is a selective p38α and c-Met PROTAC degrader. SJF-8240 promotes the ubiquitination and selective degradation of p38α and c-Met. SJF-8240 is applicable to breast cancer-related research.
(Pink: p38α and c-Met ligand (HY-45124); Blue: VHL ligand (HY-125845); Black: linker (HY-W442078)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.33%
- CAS 番号: 2230821-68-6
- 分子式: C58H65F2N7O11S
- 分子量:1106.24
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保管条件:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
More
生物活性
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p38α |
c-Met |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
50 nM
Compound: Example 1
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Protac activity at E3 ubiquitin ligase/p38alpha in human MDA-MB-231 cells assessed as p38alpha degradation after 4 hrs by ELISA
Protac activity at E3 ubiquitin ligase/p38alpha in human MDA-MB-231 cells assessed as p38alpha degradation after 4 hrs by ELISA
|
[PMID: 30783495] |
化学情報
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CAS 番号 2230821-68-6
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性状 Solid
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分子量 1106.24
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分子式 C58H65F2N7O11S
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Color White to light yellow
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SMILES
FC1=CC=C(C=C1)NC(C2(C(NC3=CC(F)=C(C=C3)OC4=CC=NC5=C4C=C(C(OCCCOCCCOCCC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=C5)OC)=O)CC2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (90.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019;10(1):131. Published 2019 Jan 10. [Content Brief]
[3]. Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9040 mL | 4.5198 mL | 9.0396 mL | 22.5991 mL |
| 5 mM | 0.1808 mL | 0.9040 mL | 1.8079 mL | 4.5198 mL | |
| 10 mM | 0.0904 mL | 0.4520 mL | 0.9040 mL | 2.2599 mL | |
| 15 mM | 0.0603 mL | 0.3013 mL | 0.6026 mL | 1.5066 mL | |
| 20 mM | 0.0452 mL | 0.2260 mL | 0.4520 mL | 1.1300 mL | |
| 25 mM | 0.0362 mL | 0.1808 mL | 0.3616 mL | 0.9040 mL | |
| 30 mM | 0.0301 mL | 0.1507 mL | 0.3013 mL | 0.7533 mL | |
| 40 mM | 0.0226 mL | 0.1130 mL | 0.2260 mL | 0.5650 mL | |
| 50 mM | 0.0181 mL | 0.0904 mL | 0.1808 mL | 0.4520 mL | |
| 60 mM | 0.0151 mL | 0.0753 mL | 0.1507 mL | 0.3767 mL | |
| 80 mM | 0.0113 mL | 0.0565 mL | 0.1130 mL | 0.2825 mL |
SJF-8240 関連分類
HY-123961 関連分類
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