Teixobactin
Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1613225-53-8
- 分子式: C58H95N15O15
- 分子量:1242.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Antibiotic アイソフォーム固有の製品をすべて表示
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生物活性
Teixobactin (0-128 µg/mL) shows antibacterial activity with a MIC value of 0.25 µg/mL for MRSA ATCC 33591[2].
Teixobactin (0-24 h) shows antibacterial activity with MIC values of 5, 20 ng/mL for Clostridium difficile, Bacillus anthracis, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CD-1 mice (MRSA ATCC33591)[3]
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Dosage:1, 2.5, 5, 10, 20 mg/kg
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Administration:i.v.; once; one hour post-infection
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Result:Showed good antibacterial activity and all treated animals survived.
化学情報
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CAS 番号 1613225-53-8
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分子量 1242.47
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分子式 C58H95N15O15
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology? J Antimicrob Chemother. 2015 Oct;70(10):2679-80. [Content Brief]
[2]. Parmar A, et al. Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chem Sci. 2017 Dec 1;8(12):8183-8192. [Content Brief]
[3]. Ling LL, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517(7535):455-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Teixobactin 関連分類
HY-P0230 関連分類
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