Triptriolide
Triptriolide inhibits Puromycin aminonucleoside PAN (HY-15695)-induced apoptosis in mouse podocytes through regulation of Bcl-2 family proteins and inhibition of Caspase-3. Triptriolide promotes the cell survival, protects and restores the podocyte function through activation of TAK1-NF-κB signaling pathway and upregulation of podocin.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 137131-18-1
- 分子式: C20H26O7
- 分子量:378.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BGC-823 | IC50 |
>10 μM
Compound: 8d
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Cytotoxicity against human BGC-823 cells by MTT assay
Cytotoxicity against human BGC-823 cells by MTT assay
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[PMID: 33289552] |
| HCT-116 | IC50 |
>10 μM
Compound: 8d
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Cytotoxicity against human HCT-116 cells by MTT assay
Cytotoxicity against human HCT-116 cells by MTT assay
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[PMID: 33289552] |
| HepG2 | IC50 |
>10 μM
Compound: 8d
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Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
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[PMID: 33289552] |
化学情報
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CAS 番号 137131-18-1
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分子量 378.42
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分子式 C20H26O7
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SMILES
C[C@@]12[C@@]34[C@]5([C@@H]([C@@](O)([C@@H]([C@]3([H])O4)O)C(C)C)O)[C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Triptriolide 関連分類
HY-N15315 関連分類
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