VU0285683
Based on 1 Customer Validation
VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.76%
- CAS 番号: 327056-22-4
- 分子式: C14H7FN4O
- 分子量:266.23
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.025 μM
Compound: 7s
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Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellular Ca2+ level after 30 mins by FLIPR assay
Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellular Ca2+ level after 30 mins by FLIPR assay
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[PMID: 23046966] |
化学情報
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CAS 番号 327056-22-4
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性状 Solid
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分子量 266.23
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分子式 C14H7FN4O
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Color White to off-white
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SMILES
N#CC1=CC(C2=NC(C3=NC=CC=C3)=NO2)=CC(F)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (187.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7562 mL | 18.7808 mL | 37.5615 mL | 93.9038 mL |
| 5 mM | 0.7512 mL | 3.7562 mL | 7.5123 mL | 18.7808 mL | |
| 10 mM | 0.3756 mL | 1.8781 mL | 3.7562 mL | 9.3904 mL | |
| 15 mM | 0.2504 mL | 1.2521 mL | 2.5041 mL | 6.2603 mL | |
| 20 mM | 0.1878 mL | 0.9390 mL | 1.8781 mL | 4.6952 mL | |
| 25 mM | 0.1502 mL | 0.7512 mL | 1.5025 mL | 3.7562 mL | |
| 30 mM | 0.1252 mL | 0.6260 mL | 1.2521 mL | 3.1301 mL | |
| 40 mM | 0.0939 mL | 0.4695 mL | 0.9390 mL | 2.3476 mL | |
| 50 mM | 0.0751 mL | 0.3756 mL | 0.7512 mL | 1.8781 mL | |
| 60 mM | 0.0626 mL | 0.3130 mL | 0.6260 mL | 1.5651 mL | |
| 80 mM | 0.0470 mL | 0.2348 mL | 0.4695 mL | 1.1738 mL | |
| 100 mM | 0.0376 mL | 0.1878 mL | 0.3756 mL | 0.9390 mL |
VU0285683 関連分類
HY-103571 関連分類
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